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Solvent-Free Cyanosilylation of Aldehydes and Anti-cervical Cancer Activity of a Highly Porous Zinc-MOF

  • Rong Li
  • Yan-Na Yue
  • Jing Sun
  • Ye Fang
  • Xiao-Hong Ge
  • Li-Ping ZhangEmail author
Original Paper
  • 17 Downloads

Abstract

A new three-dimensional (3D) zinc(II) metal–organic framework (MOF) {[Zn2(abtc)(H2O)3](DMA)}n bearing the rigid organic ligand 3,3′,5,5′-azobenzene-tetracarboxylic acid (H4abtc) were prepared by reaction of zinc(II) nitrate and H4abtc in a mixed solvent of DMA and water at 80 °C for 3 days. Compared with pristine hydrated 1, the dehydrated 1a exhibits highly efficient catalytic activity for cyanosilylation of carbonyl compounds with a low catalyst loading of 0.1 mol% at room temperature under solvent-free conditions, which due to the open Zn2+ sites as catalytically activated sites played a significant role in the heterogeneous catalytic process. Based on the experimental results, a possible reaction mechanism has also been proposed. Next, the inhibitory effect of compound 1a on Hela cervical cancer cell viability was evaluated by CCK-8 assay, and the percentage of cell cycles was determined in flow cytometry. Besides, the transwell assay also performed to detect the effect of compound 1a on cell migration and invasion.

Keywords

Metal–organic framework Open metal sites Porous framework Cyanosilylation reaction 

Notes

Supplementary material

10876_2019_1615_MOESM1_ESM.cif (523 kb)
Supplementary material 1 (CIF 522 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Rong Li
    • 1
  • Yan-Na Yue
    • 1
  • Jing Sun
    • 1
  • Ye Fang
    • 2
  • Xiao-Hong Ge
    • 1
  • Li-Ping Zhang
    • 3
    Email author
  1. 1.Department of Gynaecology and ObstetricsNingbo Yinzhou No.2 HospitalNingboChina
  2. 2.Department of UltrasoundNingbo Yinzhou No.2 HospitalNingboChina
  3. 3.Department of Gynaecology and ObstetricsYanan University Affiliated HospitalYan’anChina

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