In Vivo Non-toxicity of Gold Nanoparticles on Wistar Rats

  • Tamilselvan SelvarajEmail author
  • Ashokkumar Thirunavukkarasu
  • Soniya Murali Rathnavelu
  • Govindaraju Kasivelu
Original Paper


A comparative toxicity studies were conducted with biologically and chemically synthesized gold nanoparticles (AuNPs). Biomolecules such as propanoic acid 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl) (PAT) and proanthocyanidin (PAC) were used for biologically synthesized AuNPs and sodium citrate was used for chemically synthesized AuNPs. These synthesized AuNPs were characterized using UV–vis spectroscopy and Transmission electron microscopic. Rats were orally administered with PAT, PAC and citrate synthesized AuNPs at the dose of 5 mg/kg body weight for 28 days. Serum biochemical analysis, hematology and histochemical studies were carried out. The results indicated that the AuNPs synthesized using citrate induced toxicity whereas biomolecules (PAT and PAC) functionalized AuNPs did not show any toxicity. In conclusion, biologically mediated AuNPs can be used as effective as drug molecules or a carrier molecule for drug delivery.


Gold nanoparticles Nanotoxicity In vivo Wistar rats 



We thank to the DST-SERB, New Delhi, India for financial support and also the Adhiparasakthi College of Arts and Science, Kalavai, Vellore, Tamilnadu.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Tamilselvan Selvaraj
    • 1
    Email author
  • Ashokkumar Thirunavukkarasu
    • 2
  • Soniya Murali Rathnavelu
    • 3
  • Govindaraju Kasivelu
    • 1
  1. 1.Centre for Ocean ResearchSathyabama Institute of Science and TechnologyChennaiIndia
  2. 2.Department of MicrobiologySchool of Basic Medical Sciences Taramani, University of MadrasChennaiIndia
  3. 3.Department of PharmaceuticsSri Venkateshwara College of PharmacyChittoorIndia

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