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Crystal Structures and Inhibiting Human Cardiac Myoma Cells Activity of Co(II) and Cu(II)-based Coordination Polymers Constructed from 4-(1H-pyrazole-4-yl)benzoic Acid and 4,4′-Bipyridine Ligands

  • Wei-Feng Zheng
  • Hui-Fang Ma
  • Xue-Wei Chang
  • Shou-Yan Zhang
Original Paper
  • 14 Downloads

Abstract

Two new coordination polymers [Co2(L)2(4,4′-bipy)(H2O)2](DMA)2 (1, 4,4′-bipy = 4,4′-bipyridine, H2L = 4-(1H-pyrazole-4-yl)benzoic acid) and [Cu2(L)2(4,4′-bipy)](DEF)3 (2, DEF = N, N-diethylformamide), have been synthesized via solvothermal reaction of M(NO3)2·6H2O (M = Co for 1 and Cu for 2) with the pyrazolate/carboxylate ligand and the 4,4′-bipy linker. Both coordination polymer architectures in nanoscale regimes have been prepared and determined via PXRD and SEM, and the cytotoxicity of them against the human cardiac myoma cells H9C2 has been evaluated via the MTT assay with the cisplatin as the reference drug, which demonstrates better anticancer activities of the both nano architectures than those of their samples in micro regimes.

Keywords

Coordination polymers Mixed-ligand Nano architectures Anticancer activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Wei-Feng Zheng
    • 1
  • Hui-Fang Ma
    • 1
  • Xue-Wei Chang
    • 1
  • Shou-Yan Zhang
    • 1
  1. 1.Department of Cardiovascular MedicineLuoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyangChina

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