Journal of Cluster Science

, Volume 29, Issue 6, pp 1269–1274 | Cite as

Bifunctional (3,6)-Connected Gd(III) Metal–Organic Framework Material with Catalytic Properties for the Cyanosilylation Reaction and Anti-gastric Cancer Activity

  • Zhou-Feng Chen
  • Hai-Bo Xue
  • Lei-Ruo Wu
  • Rui-Fang JinEmail author
Original Paper


A new Gd(III) coordination polymer, namely [Gd(bpt)(H2O)(DMF)]n·3n(H2O) (1, H3bpt = biphenyl-3,4′,5-tricarboxylic acid, DMF = N,N-dimethylformamide), has been successfully synthesized under solvothermal conditions. In the structure of 1, the dinuclear [Gd2(COO)4] building subunits are connected by the bpt3− ligands into a 3D framework with (3,6)-connected flu-3,6-C2/c topology. Moreover, the catalytic performances of 1 and 1′ (desolvated sample) towards the cyanosilylation of benzaldehyde and its derivatives have been tested under mild conditions. The catalytic activity of 1′ is higher than that of compound 1, indicating that more open metal sites in coordination polymer is beneficial to the cyanosilylation reaction. In addition, in vitro anticancer activities of compounds 1 and 1′ (desolvated sample) on four human gastric cancer cells (MGC-803, SGC-790, MKN45 and AGS) were further determined.


Gd(III) compound Biphenyl-3,4′,5-tricarboxylic acid Solvothermal reaction Cyanosilylation reaction Anti-gastric cancer activity 

Supplementary material

10876_2018_1445_MOESM1_ESM.doc (1.4 mb)
Supplementary material 1 (DOC 1476 kb)


  1. 1.
    Y. Wang, Z. Liu, Y. Li, Z. Bai, W. Liu, Y. Wang, X. Xu, C. Xiao, D. Sheng, J. Diwu, J. Su, Z. Chai, T. E. Albrecht-Schmitt, and S. Wang (2015). J. Am. Chem. Soc. 137, 6144.CrossRefPubMedGoogle Scholar
  2. 2.
    J. Xie, Y. Wang, W. Liu, X. Yin, L. Chen, Y. Zou, J. Diwu, Z. Chai, T. E. Albrecht-Schmitt, G. Liu, and S. Wang (2017). Angew. Chem. Int. Ed. 56, 7500.CrossRefGoogle Scholar
  3. 3.
    Y. Li, Z. Yang, Y. Wang, Z. Bai, T. Zheng, X. Dai, S. Liu, D. Gui, W. Liu, and M. Chen (2017). Nat. Commun. 8, 1354.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    X. Wang, Y. Wang, X. Dai, M. A. Silver, W. Liu, Y. Li, Z. Bai, D. Gui, L. Chen, J. Diwu, R. Zhou, Z. Chai, and S. Wang (2018). Chem. Commun. 54, 627.CrossRefGoogle Scholar
  5. 5.
    B. Liu, H. F. Zhou, Z. H. Guan, L. Hou, B. Cui, and Y. Y. Wang (2016). Green Chem. 18, 5418.CrossRefGoogle Scholar
  6. 6.
    J. Liu, L. Chen, H. Cui, J. Zhang, L. Zhang, and C. Y. Su (2014). Chem. Soc. Rev. 43, 6011.CrossRefPubMedGoogle Scholar
  7. 7.
    M. X. Wu and Y. W. Yang (2017). Adv. Mater. 29, 1606134.CrossRefGoogle Scholar
  8. 8.
    N. Kurono and T. Ohkuma (2016). ACS Catal. 6, 989.CrossRefGoogle Scholar
  9. 9.
    Z. Ma, A. V. Gurbanov, M. Sutradhar, M. N. Kopylovich, K. T. Mahmudov, A. M. Maharramov, F. I. Guseinov, F. I. Zubkov, and A. J. L. Pombeiro (2017). Mol. Catal. 428, 17.CrossRefGoogle Scholar
  10. 10.
    I. H. Choi, Y. Kim, D. N. Lee, and S. Huh (2016). Polyhedron 105, 96.CrossRefGoogle Scholar
  11. 11.
    A. V. Gurbanov, K. T. Mahmudov, M. Sutradhar, F. C. Guedes da Silva, T. A. Mahmudov, F. I. Guseinov, F. I. Zubkov, A. M. Maharramov, and A. J. L. Pombeiro (2017). J. Organomet. Chem. 834, 22.CrossRefGoogle Scholar
  12. 12.
    A. Fujii, J. C. Choi, and K. Fujita (2017). Tetrahedron Lett. 58, 1515.CrossRefGoogle Scholar
  13. 13.
    A. V. Gurbanov, G. Mahmoudi, M. F. C. Guedes da Silva, F. I. Zubkov, K. T. Mahmudov, and A. J. L. Pombeiro (2018). Inorg. Chim. Acta 471, 130.CrossRefGoogle Scholar
  14. 14.
    Y. P. Li, L. J. Zhang, and W. J. Ji (2017). J. Mol. Struct. 1133, 607.CrossRefGoogle Scholar
  15. 15.
    A. V. Gurbanov, A. M. Maharramov, F. I. Zubkov, A. M. Saifutdinov, and F. I. Guseinov (2018). Aust. J. Chem. 71, 190.CrossRefGoogle Scholar
  16. 16.
    H. K. Kim, W. S. Yun, M. B. Kim, J. Y. Kim, Y. S. Bae, J. Lee, and N. C. Jeong (2015). J. Am. Chem. Soc. 137, 10009.CrossRefPubMedGoogle Scholar
  17. 17.
    S. Shen, Y. Wu, K. Li, Y. Wang, J. Wu, Y. Zeng, and D. Wu (2018). Biomaterials 154, 197.CrossRefPubMedGoogle Scholar
  18. 18.
    X. J. Li, K. Zheng, Y. T. Li, C. W. Yan, Z. Y. Wu, and S. Y. Xuan (2015). J. Coord. Chem. 68, 928.CrossRefGoogle Scholar
  19. 19.
    J. Li and J. T. Li (2018). Inorg. Chem. Commun. 89, 51.CrossRefGoogle Scholar
  20. 20.
    J. Li, X. H. Ji, and J. T. Li (2017). J. Mol. Struct. 1147, 22.CrossRefGoogle Scholar
  21. 21.
    S. Y. Hao, S. X. Hao, K. Van Hecke, and G. H. Cui (2017). Dalton Trans. 46, 1951.CrossRefPubMedGoogle Scholar
  22. 22.
    Y. Zhu, Y. M. Wang, S. Y. Zhao, P. Liu, C. Wei, Y. L. Wu, C. K. Xia, and J. M. Xie (2014). Inorg. Chem. 53, 7692.CrossRefPubMedGoogle Scholar
  23. 23.
    F. Guo, F. Wang, X. L. Zhang, and J. Zhang (2012). Inorg. Chem. 51, 9677.CrossRefPubMedGoogle Scholar
  24. 24.
    Z. X. Xu, Y. L. Ma, and J. Zhang (2016). Chem. Commun. 52, 1923.CrossRefGoogle Scholar
  25. 25.
    T. F. Liu, J. Lu, C. B. Tian, M. N. Cao, Z. J. Lin, and R. Cao (2011). Inorg. Chem. 50, 2264.CrossRefPubMedGoogle Scholar
  26. 26.
    S. S. Xiong, Y. B. He, R. Krishna, B. L. Chen, and Z. Y. Wang (2013). Cryst. Growth Des. 13, 2670.CrossRefGoogle Scholar
  27. 27.
    S. T. Zheng, D. Q. Yuan, J. Zhang, and G. Y. Yang (2007). Inorg. Chem. 46, 4569.CrossRefPubMedGoogle Scholar
  28. 28.
    Y. Zhu, M. Zhu, P. Lin, L. Xia, Y. L. Wu, and J. M. Xie (2017). J. Mol. Struct. 1130, 26.CrossRefGoogle Scholar
  29. 29.
    G. M. Sheldrick SADABS (University of Göttingen, Göttingen, Germany, 1996).Google Scholar
  30. 30.
    G. M. Sheldrick SHELXS 97, Program for Solution of Crystal Structures (University of Göttingen, Göttingen, Germany, 1997).Google Scholar
  31. 31.
    Y. L. Wu, J. Qian, G. P. Yang, F. Yang, Y. T. Liang, W. Y. Zhang, and Y. Y. Wang (2017). Inorg. Chem. 56, 908.CrossRefPubMedGoogle Scholar
  32. 32.
    Y. Wu, G. P. Yang, J. Liu, Y. Yan, X. Luan, W. Y. Zhang, and Y. Y. Wang (2016). CrystEngComm 18, 5901.CrossRefGoogle Scholar
  33. 33.
    X. Cui, M. C. Xu, L. J. Zhang, R. X. Yao, and X. M. Zhang (2015). Dalton Trans. 44, 12711.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Zhou-Feng Chen
    • 1
  • Hai-Bo Xue
    • 1
  • Lei-Ruo Wu
    • 1
  • Rui-Fang Jin
    • 1
    Email author
  1. 1.Department of GastrologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina

Personalised recommendations