Emerging Theranostic Biogenic Silver Nanomaterials for Breast Cancer: A Systematic Review

  • Hamed BarabadiEmail author
  • Mohammad Ali Mahjoub
  • Babak Tajani
  • Amirhossein Ahmadi
  • Yasmeen Junejo
  • Muthupandian SaravananEmail author
Review Paper


Breast cancer remains the second common cause of cancer death in United State women in 2018. Consequently, it is of growing need to explore new strategies to treat cancer at various stages of breast cancer. This review discussing the efficacy of biogenic silver nanoparticles (AgNPs) against breast cancer and/or normal cells and its mechanisms of AgNPs toxicity. The research articles were systematically collected through databases including Cochrane, Web of Science, PubMed, Scopus, Science Direct, ProQuest, Google Scholar, and Embase. Significantly, most of the studies were carried out on MCF-7 cancer cell line. Furthermore, the general approach was phyto-fabrication of AgNPs. Specifically, a hefty 71.27% of studies employed plants to bio-fabricate AgNPs. Additionally, fungi with 14.89% of the studies were the second predominant resources conducted for synthesis of AgNPs. Majority of studies bio-fabricated spherical AgNPs with an average diameter of less than 100 nm. Interestingly, the general approach suggested significant toxic effects of biogenic AgNPs with inhibitory concentration of 50% in breast cancer cell lines, while less toxicity was reported in normal cell lines. Regarding the recent advantages in cancer nanomedicine, it is expected that biogenic AgNPs may emerge as potential breast cancer therapeutic agents alone or in combination with FDA-approved anti-cancer drugs in the near future.


Cancer nanomedicine Nanotoxicity Green synthesis Silver nanoparticles Breast cancer 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pharmaceutical Biotechnology, School of PharmacyShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Pharmaceutics, School of PharmacyShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Faculty of Pharmacy, Pharmaceutical Sciences Research CenterMazandaran University of Medical SciencesSariIran
  4. 4.Department of BiologyVirtual University of Pakistan-MultanMultanPakistan
  5. 5.Department of Medical Microbiology and Immunology, Institute of Biomedical Sciences, College of Health SciencesMekelle UniversityMekelleEthiopia

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