Two Prenatal Cases of Hyper-IgE Syndrome
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To the Editor:
Autosomal dominant hyper-IgE syndrome (AD-HIES), a rare primary immunodeficiency disorder caused by mutations in STAT3 (signal transducer and activator of transcription factor 3), is characterized by recurrent staphylococcal skin abscesses, pulmonary infections, and high serum IgE concentrations . There are few reports on pregnancy and childbirth in women with AD-HIES. Here, we report the pregnancies of two women with AD-HIES whose infants had the same STAT3 mutation.
We thank the patients who participated in this study.
ME wrote the manuscript and managed the pregnancies. KI and TM orchestrated the patients’ care. KI and YT reviewed the manuscript. All authors reviewed the manuscript and approved the final version.
This work was partially supported by the Japan Ministry of Health, Labor, and Welfare (201711064A) and the AMED under Grant Number JP18ek0109218.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
Research Involving Human Participants
All procedures performed in the study were in accordance with the Helsinki principles.
Written informed consent was obtained from both patients here presented.