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Interleukin 8 and Susceptibility to Coronary Artery Disease: a Population Genetics Perspective.

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Abstract

Introduction

Interleukin 8 is a strong chemoattractant factor for neutrophils and T lymphocytes. We investigated the potential influence of two common polymorphisms of the interleukin-8 gene, −251A/T, and 781C/T on susceptibility to coronary artery disease.

Materials and Methods

The hypothesis was tested by screening for the prevalence of the above polymorphisms in 241 angiographically diagnosed coronary artery disease patients compared to 157 selected controls with negative coronary angiography.

Results and Discussion

We found no significant differences between cases and controls concerning the allelic and genotypic frequencies of both the studied polymorphisms. Nevertheless, a statistically significant lower frequency of the AA containing genotypes was observed in cases presenting with acute coronary syndromes compared to asymptomatic subjects or patients with stable coronary artery disease (OR = 0.44, 95%CI: 0.2–0.98, p = 0.04). The strongest statistical significance was observed in the AA251TT781 combined genotype (OR = 0.34, 95%CI: 0.14–0.85, p = 0.02).

Conclusion

Our results suggest that the genetic diversity of the interleukin-8 gene influences the clinical manifestation of CAD.

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Authors and Affiliations

  1. Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece

    Konstantina Vogiatzi, Stavros Apostolakis & Demetrios A. Spandidos

  2. Department of Cardiology, Onassis Cardiac Surgery Centre, Athens, Greece

    Vassilios Voudris & Sophia Thomopoulou

  3. Department of Cardiology, University Hospital of Crete, Heraklion, Crete, Greece

    Georgios E. Kochiadakis

Authors
  1. Konstantina Vogiatzi
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  2. Stavros Apostolakis
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  3. Vassilios Voudris
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  4. Sophia Thomopoulou
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  5. Georgios E. Kochiadakis
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  6. Demetrios A. Spandidos
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Correspondence to Demetrios A. Spandidos.

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Vogiatzi, K., Apostolakis, S., Voudris, V. et al. Interleukin 8 and Susceptibility to Coronary Artery Disease: a Population Genetics Perspective.. J Clin Immunol 28, 329–335 (2008). https://doi.org/10.1007/s10875-008-9194-3

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  • DOI: https://doi.org/10.1007/s10875-008-9194-3

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