N-Valine-2-(3,5-dimethy-1,1-dioxido-2H-1,2,6-thiadiazin-4-yl)Benzamide: Synthesis, X-ray Structure and Hirshfeld Surface Analysis

  • Marivel Samipillai
  • Nilay Bhatt
  • Pralav Bhatt
  • Thavendran Govender
  • Hendrick G. Kruger
  • Glenn E. M. MaguireEmail author
Original Paper


Here we report the synthesis and crystal structure of the title compound N-valine-2-(3,5-dimethy-1,1-dioxido-2H-1,2,6-thiadiazin-4-yl)benzamide, C18H23N3O5S. The structure was determined by the single crystal X-ray diffraction method. The compound crystallized in a monoclinic Sohncke space C2 space group with cell values of a = 18.3096 (11) Å, b = 7.4858 (5) Å, c = 14.1452 (10) Å, β = 90.176 (2)° and with Z = 4. Crystal structure analysis showed that the molecule is not planar and the thiadiazine ring is essentially orthogonal to the plane passing through the aromatic ring. The dihedral angle between the thiadiazine ring and the aromatic ring is 93.72°. The carbonyl of the amide bond deviates from co-planarity of the aromatic ring by 60.03° which is perhaps due to the steric hindrance of the carbonyl group towards the thiadiazine ring. The sulfur atom deviates from the mean plane of the ring by 0.102 Å.

Graphical Abstract

The synthesis of the title compound, N-valine-2-(3,5-dimethy-1,1-dioxido-2H-1,2,6-thiadiazin-4-yl)benzamide, and its structural characterization by means of single crystal X-ray diffraction and Hirshfeld surface analysis are reported.


S,S-dioxides Thiadiazine Valine derivative X-ray structure Hirshfeld analysis 



The authors wish to thank Dr Hong Su from the University of Cape Town for assistance with the data collection and refinement.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Marivel Samipillai
    • 1
  • Nilay Bhatt
    • 1
  • Pralav Bhatt
    • 1
  • Thavendran Govender
    • 1
  • Hendrick G. Kruger
    • 1
  • Glenn E. M. Maguire
    • 2
    Email author
  1. 1.Catalysis and Peptide Research Unit, School of Health SciencesUniversity of KwaZulu–NatalDurbanSouth Africa
  2. 2.School of Chemistry and PhysicsUniversity of KwaZulu–NatalDurbanSouth Africa

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