Biomimetic coatings and negative pressure wound therapy independently limit epithelial downgrowth around percutaneous devices
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This work was supported in part by the Department of Defense [#W81XWH-11-1-0435, 2010], by the United States Department of Veterans Affairs Rehabilitation Research and Development Service under Merit Review Award [#I01RX001217, 2014], and by the Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah. The views, opinions, and/or findings presented are those of the authors and should not be construed as an official position, policy or decision of any of these funding sources unless so designated by other documentation. In conducting research using animals, the investigators adhered to the Animal Welfare Act Regulations and other Federal statutes relating to animals and experiments involving animals and the principles set forth in the current version of the Guide for Care and Use of Laboratory Animals, National Research Council. The authors wish to express their sincere gratitude to Thortex Inc. (Portland, OR) for device fabrication and coating support. They also wish to acknowledge the Bone and Joint Research Laboratory’s Histology Team for their technical expertize with the samples embedment process, and Greg Stoddard for his help with statistical analysis.
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Conflict of interest
The authors declare that they have no conflict of interest.
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