Self assembly and controlled drug release of a nano-laminated graphite carbon nitride/methotrexate complex

  • Shanshan Liu
  • Zhaoliang Guo
  • Xiongfeng Zeng
  • Xianguang Meng
  • Haina Sun
  • Yizao Wan
  • Guifu ZuoEmail author
Delivery Systems Rapid Communication
Part of the following topical collections:
  1. Delivery Systems


In this study, g-C3N4/methotrexate (g-C3N4/MTX) nanohybrids were obtained via a self assembly method. XRD and TEM demonstrated that bulk g-C3N4 had been stripped into thin nanosheets with size range of 150–250 nm. FTIR investigation indicated that the self assembly of the hybrid was attributed to the hydrogen bond between g-C3N4 nanosheets and MTX molecules. It is confirmed by the UV-vis spectra that the hybrids can achieve a sustained drug release within long period for 70 h. Furthermore, the drug release mechanism was investigated by kinetic models and a first-order relationship was concluded, which indicated that the drug release is a simple diffusion process cohydroxyapatite/methotrexate complexntrolled by gradient drug concentration. Cell viability tests confirmed that g-C3N4 presented excellent biocompatibility and g-C3N4/MTX hybrids had obvious suppression efficiency on MG63 cells which showed a positive correlation to the drug concentration and incubation time.



This work was supported by the National Natural Science Foundation of China (Grant No. 51502075) and Outstanding Youth Funds of North China University of Science and Technology (Grant No. JP201604).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Authors and Affiliations

  1. 1.Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials, College of Materials Science and EngineeringNorth China University of Science and TechnologyTangshanP. R. China
  2. 2.School of Materials Science and EngineeringTianjin UniversityTianjinP. R. China

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