Ultra-long ZnO/carbon nanofiber as free-standing electrochemical sensor for dopamine in the presence of uric acid

  • Chi YangEmail author
  • Chunyan Zhang
  • Tong Huang
  • Xiuxiu Dong
  • Langqin Hua
Materials for life sciences


Dopamine (DA) and uric acid (UA) have similar peak potentials in vivo, and it is difficult to distinguish them by general electrode material. Here, we used a magnetron sputtering method to sputter the ZnO seed layer on carbon fiber and prepare ultra-long ZnO nanofibers/carbon fibers (ZnO NF/CF) electrode by in situ hydrothermal method. As a free-standing electrode, not only electrochemical detection of DA and UA but also a separation of oxidation potential peaks of DA and UA can be achieved. In addition, in the case of high concentration UA (0.1 mM), ZnO NF/CF shows high sensitivity and selectivity and shows a wide linear range for DA (4–20 µM). Meanwhile, we proposed the electrochemical mechanism and process of DA and UA on the surface of ZnO, which helps us to understand the simultaneous detection of DA and UA by such electrochemical electrodes.



This work was supported by the National Natural Science Foundation of China (Grant Nos. 91644103, 41603104, 61404075), the National Key Research and Development Program of China (2017YFC0212302), the Postdoctoral Foundation of Jiangsu Province (1601090B), the China Postdoctoral Science Foundation (2016M601694), and the Natural Science Foundation for Young Scientists of Jiangsu Province, China (BK20150895). Also including the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (PCSIRT) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). At the same time, we also thank Professor Yanlin Zhang for his support and discussion.

Compliance with ethical standards

Conflict of interest

All the authors have declared that: (1) no support, financial or otherwise, has been received from any organization that may have an interest in the submitted work, and (2) there are no other relationships or activities that could appear to have influenced the submitted work.

Supplementary material

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Supplementary material 1 (PDF 1412 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Yale-NUIST Center on Atmospheric Environment, International Joint Laboratory on Climate and Environment Change (ILCEC), School of Applied MeteorologyNanjing University of Information Science and TechnologyNanjingChina
  2. 2.State Key Laboratory of Bioelectronics, School of Biological Science and Medical EngineeringSoutheast UniversityNanjingChina

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