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Dual ionically cross-linked hydrogels with ultra-tough, stable, and self-healing properties

  • Bo Xu
  • Xiong Zhang
  • Shuchun Gan
  • Jianhao Zhao
  • Jianhua RongEmail author
Polymers & biopolymers
  • 23 Downloads

Abstract

Excellent mechanical and self-healing features could make hydrogels an ideal candidate for the application of load-bearing soft tissue replacements such as cartilage. In this study, a dual ionically cross-linked 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC)/poly(acrylic acid) (PAAc)-Fe3+ hydrogel was constructed using a one-pot method (in situ polymerization of AAc in the presence of HACC and Fe3+). Both macromolecular positively charged HACC and Fe3+ metal ions acted as cross-linkers to form ionic bonds with negatively charged PAAc. The HACC/PAAc-Fe3+ hydrogels demonstrated ultra-high mechanical strengths (tensile strength of ca. 9.86 MPa and compressive stresses greater than 95 MPa at 99% strain), excellent self-recoverability (ca. over 90% toughness recovery within 5 h without any external stimuli), outstanding self-healing properties (ca. 74% self-healing efficiency at 70 °C for 48 h), transparency, and high stabilities in aqueous environments. The mechanical properties of the hydrogels could be adjusted by varying the concentration of HACC and Fe3+. This work provides a new approach for the construction of novel tough and transparent hydrogels with a fully ionically cross-linked network.

Abbreviations

3T3

Mouse embryo fibroblasts

AAc

Acroleic acid

APS

Ammonium persulfate

ATR-FTIR

Attenuated total reflectance Fourier-transform infrared

CCK-8

Cell counting kit-8

DMEM

Dulbecco’s modified eagle’s medium

FBS

Fetal bovine serum

HACC

2-Hydroxypropyltrimethyl ammonium chloride chitosan

PAAc

Polyacrylic acid

PAM

Polyacrylamide

SEM

Scanning electron microscope

UV–Vis

Ultraviolet–visible

XG

Xanthan gum

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 51173070), National Natural Science Foundation of Guangdong, China (No. 2016A030313097), and the Science and Technology Program of Guangzhou, China (No. 201707010264).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10853_2019_3773_MOESM1_ESM.docx (2.5 mb)
Supplementary material 1 (DOCX 2509 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Materials Science and Engineering, College of Chemistry and Materials ScienceJinan UniversityGuangzhouChina

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