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Journal of Materials Science

, Volume 54, Issue 17, pp 11682–11693 | Cite as

Fabrication of a novel antibacterial TPU nanofiber membrane containing Cu-loaded zeolite and its antibacterial activity toward Escherichia coli

  • Jingjing Lei
  • Guangyuan Yao
  • Zhiming SunEmail author
  • Bin WangEmail author
  • Caihong Yu
  • Shuilin Zheng
Materials for life sciences

Abstract

A novel antibacterial thermoplastic polyurethane (TPU) nanofiber membrane was fabricated by electrospinning with the aid of Cu-loaded NaX zeolite (CuX), which showed excellent and long-lasting antibacterial activity against Escherichia coli (E. coli). The crystalline structure, morphology and composition of the obtained NaX zeolite, CuX and CuX/TPU nanofiber membrane were analyzed by X-ray diffraction (XRD), scanning electron microscope (SEM) and X-ray fluorescence (XRF), respectively. The antibacterial activity of CuX/TPU nanofiber membrane against E. coli was investigated by inhibition zone method and plate-counting method, and it is indicated that the inactivation efficiency was increased from 58.40 to 99.85% with increasing the addition of CuX from 5 to 30% in 4 h. The result of kinetics study indicated that the disinfection process accorded with the pseudo-first-order model. The possible antibacterial mechanism was also proposed that the released Cu2+ by CuX in nanofiber membrane destroyed the cell wall and penetrated plasma membrane of E. coli. It is expected that this CuX/TPU nanofiber membrane with excellent antibacterial activity would be a promising candidate for biomedical applications.

Notes

Acknowledgements

The authors gratefully acknowledge the financial support provided by the Young Elite Scientists Sponsorship Program by CAST (2017QNRC001), Yueqi Funding Scheme for Young Scholars (China university of Mining &Technology, Beijing), Beijing Excellent Talent Training Subsidy Program (2017000020124G089), Science and technology Project of Beijing Municipal Education Commission (KM201910012010), High Levels of Teachers’ Team Construction Special Funds of Beijing Institute of Fashion Technology (BIFTQG201807) and Talent introduction program of Beijing Institute of Fashion Technology (2017A-19).

References

  1. 1.
    Zhang J, Woodruff TM, Clark RJ, Martin DJ, Minchin RF (2016) Release of bioactive peptides from polyurethane films in vitro and in vivo: effect of polymer composition. Acta Biomater 41:264–272Google Scholar
  2. 2.
    Bazmara B, Tahersima M, Behravan A (2018) Influence of thermoplastic polyurethane and synthesized polyurethane additive in performance of asphalt pavements. Constr Build Mater 166:1–11Google Scholar
  3. 3.
    Dong M, Li Q, Liu H, Liu C, Wujcik EK, Shao Q, Ding T, Mai X, Shen C, Guo Z (2018) Thermoplastic polyurethane-carbon black nanocomposite coating: fabrication and solid particle erosion resistance. Polymer 158:381–390Google Scholar
  4. 4.
    Li Y, Zhou B, Zheng G, Liu X, Li T, Yan C, Cheng C, Dai K, Liu C, Shen C, Guo Z (2018) Continuously prepared highly conductive and stretchable SWNT/MWNT synergistically composited electrospun thermoplastic polyurethane yarns for wearable sensing. J Mater Chem C 6:2258–2269Google Scholar
  5. 5.
    Ke K, Solouki Bonab V, Yuan D, Manas-Zloczower I (2018) Piezoresistive thermoplastic polyurethane nanocomposites with carbon nanostructures. Carbon 139:52–58Google Scholar
  6. 6.
    Chen R, Zhang X, Wang P, Xie K, Jian J, Zhang Y, Zhang J, Yuan Y, Na P, Yi M, Xu J (2018) Transparent thermoplastic polyurethane air filters for efficient electrostatic capture of particulate matter pollutants. Nanotechnology 30:015703Google Scholar
  7. 7.
    Ren M, Zhou Y, Wang Y, Zheng G, Dai K, Liu C, Shen C (2019) Highly stretchable and durable strain sensor based on carbon nanotubes decorated thermoplastic polyurethane fibrous network with aligned wave-like structure. Chem Eng J 360:762–777Google Scholar
  8. 8.
    Xing C, Guan J, Chen Z, Zhu Y, Zhang B, Li Y, Li J (2015) Novel multifunctional nanofibers based on thermoplastic polyurethane and ionic liquid: towards antibacterial, anti-electrostatic and hydrophilic nonwovens by electrospinning. Nanotechnology 26(10):105704Google Scholar
  9. 9.
    Bergmeister H, Seyidova N, Schreiber C, Strobl M, Grasl C, Walter I, Messner B, Baudis S, Fröhlich S, Marchetti-Deschmann M (2015) Biodegradable, thermoplastic polyurethane grafts for small diameter vascular replacements. Acta Biomater 11:104–113Google Scholar
  10. 10.
    Hong Y, Guan J, Fujimoto KL, Hashizume R, Pelinescu AL, Wagner WR (2010) Tailoring the degradation kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds. Biomaterials 31(15):4249–4258Google Scholar
  11. 11.
    Liu M, Liu T, Chen X, Yang J, Deng J, He W, Zhang X, Lei Q, Hu X, Luo G, Wu J (2018) Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing. J Nanobiotechnol 16(1):89Google Scholar
  12. 12.
    Aliabadi M, Irani M, Ismaeili J, Piri H, Parnian MJ (2013) Electrospun nanofiber membrane of PEO/Chitosan for the adsorption of nickel, cadmium, lead and copper ions from aqueous solution. Chem Eng J 220:237–243Google Scholar
  13. 13.
    Quirós J, Borges JP, Boltes K, Rodea-Palomares I, Rosal R (2015) Antimicrobial electrospun silver-, copper- and zinc-doped polyvinylpyrrolidone nanofibers. J Hazard Mater 299:298–305Google Scholar
  14. 14.
    Sill TJ, Von Recum HA (2008) Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29(13):1989–2006Google Scholar
  15. 15.
    Ghosal K, Agatemor C, Špitálsky Z, Thomas S, Kny E (2019) Electrospinning tissue engineering and wound dressing scaffolds from polymer-titanium dioxide nanocomposites. Chem Eng J 358:1262–1278Google Scholar
  16. 16.
    Song DW, Kim SH, Kim HH, Lee KH, Chang SK, Park YH (2016) Multi-biofunction of antimicrobial peptide-immobilized silk fibroin nanofiber membrane: implications for wound healing. Acta Biomater 39:146–155Google Scholar
  17. 17.
    Jiang S, Ma BC, Reinholz J, Li Q, Wang J, Zhang KAI, Landfester K, Crespy D (2016) Efficient nanofibrous membranes for antibacterial wound dressing and UV protection. ACS Appl Mater Interfaces 8:29915–29922Google Scholar
  18. 18.
    Zander ZK, Chen P, Hsu Y-H, Dreger NZ, Savariau L, McRoy WC, Cerchiari AE, Chambers SD, Barton HA, Becker ML (2018) Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications. Biomaterials 178:339–350Google Scholar
  19. 19.
    Xin J, Hao-Yang M, Salick MR, Cordie TM, Xiang-Fang P, Lih-Sheng T (2015) Electrospinning thermoplastic polyurethane/graphene oxide scaffolds for small diameter vascular graft applications. Mater Sci Eng, C 49(49):40–50Google Scholar
  20. 20.
    Yu E, Mi H-Y, Zhang J, Thomson JA, Turng L-S (2018) Development of biomimetic thermoplastic polyurethane/fibroin small-diameter vascular grafts via a novel electrospinning approach. J Biomed Mater Res A 106:985–996Google Scholar
  21. 21.
    Jiang L, Jiang Y, Stiadle J, Wang X, Wang L, Li Q, Shen C, Thibeault SL, Turng LS (2019) Electrospun nanofibrous thermoplastic polyurethane/poly(glycerol sebacate) hybrid scaffolds for vocal fold tissue engineering applications. Mater Sci Eng, C 94:740–749Google Scholar
  22. 22.
    Akduman C, Özgüney I, Kumbasar EPA (2016) Preparation and characterization of naproxen-loaded electrospun thermoplastic polyurethane nanofibers as a drug delivery system. Mater Sci Eng, C 64:383–390Google Scholar
  23. 23.
    Liu X, Zhou L, Heng P, Xiao J, Lv J, Zhang Q, Hickey ME, Tu Q, Wang J (2018) Lecithin doped electrospun poly(lactic acid)-thermoplastic polyurethane fibers for hepatocyte viability improvement. Colloids Surf B 175:264–271Google Scholar
  24. 24.
    Francolini I, D’Ilario L, Guaglianone E, Donelli G, Martinelli A, Piozzi A (2010) Polyurethane anionomers containing metal ions with antimicrobial properties: thermal, mechanical and biological characterization. Acta Biomater 6(9):3482–3490Google Scholar
  25. 25.
    Jiao L, Lin F, Cao S, Wang C, Wu H, Shu M, Hu C (2017) Preparation, characterization, antimicrobial and cytotoxicity studies of copper/zincloaded montmorillonite. J Anim Sci Biotechnol 8(1):27Google Scholar
  26. 26.
    Park SH, Ko YS, Park SJ, Lee JS, Cho J, Baek KY, Kim IT, Woo K, Lee JH (2016) Immobilization of silver nanoparticle-decorated silica particles on polyamide thin film composite membranes for antibacterial properties. J Membr Sci 499:80–91Google Scholar
  27. 27.
    Akhigbe L, Ouki S, Saroj D (2016) Disinfection and removal performance for Escherichia coli and heavy metals by silver-modified zeolite in a fixed bed column. Chem Eng J 295:92–98Google Scholar
  28. 28.
    Zhang Y, Xu C, He Y, Wang X, Xing F, Qiu H, Liu Y, Ma D, Lin T, Gao J (2011) Zeolite/polymer composite hollow microspheres containing antibiotics and the in vitro drug release. J Biomater Sci Polym Ed 22(4–6):809–822Google Scholar
  29. 29.
    Vilaça N, Amorim R, Martinho O, Reis RM, Baltazar F, Fonseca AM, Neves IC (2011) Encapsulation of α-cyano-4-hydroxycinnamic acid into a NaY zeolite. J Mater Sci 46(23):7511–7516.  https://doi.org/10.1007/s10853-011-5722-2 Google Scholar
  30. 30.
    Vilaça N, Amorim R, Machado AF, Parpot P, Pereira MFR, Sardo M, Rocha J, Fonseca AM, Neves IC, Baltazar F (2013) Potentiation of 5-fluorouracil encapsulated in zeolites as drug delivery systems for in vitro models of colorectal carcinoma. Colloids Surf B 112(1):237–244Google Scholar
  31. 31.
    Tavolaro A, Riccio II, Tavolaro P (2013) Hydrothermal synthesis of zeolite composite membranes and crystals as potential vectors for drug-delivering biomaterials. Microporous Mesoporous Mater 167:62–70Google Scholar
  32. 32.
    Khatamian M, Divband B, Farahmand-zahed F (2016) Synthesis and characterization of zinc (II)-loaded zeolite/graphene oxide nanocomposite as a new drug carrier. Mater Sci Eng, C 66:251–258Google Scholar
  33. 33.
    Amorim R, Vilaça N, Martinho O, Reis RM, Sardo M, Rocha J, Fonseca AM, Baltazar F, Neves IC (2012) Zeolite structures loading with an anticancer compound as drug delivery systems. J Phys Chem C 116(48):25642–25650Google Scholar
  34. 34.
    Iqbal N, Abdul Kadir MR, Mahmood NHB, Yusoff MFM, Siddique JA, Salim N, Froemming GRA, Sarian MN, Balaji Raghavendran HR, Kamarul T (2014) Microwave synthesis, characterization, bioactivity and in vitro biocompatibility of zeolite–hydroxyapatite (Zeo–HA) composite for bone tissue engineering applications. Ceram Int 40(10):16091–16097Google Scholar
  35. 35.
    Wang J, Wang Z, Guo S, Zhang J, Song Y, Dong X, Wang X, Yu J (2011) Antibacterial and anti-adhesive zeolite coatings on titanium alloy surface. Microporous Mesoporous Mater 146(1–3):216–222Google Scholar
  36. 36.
    Kaur B, Srivastava R, Satpati B, Kondepudi KK, Bishnoi M (2015) Biomineralization of hydroxyapatite in silver ion-exchanged nanocrystalline ZSM-5 zeolite using simulated body fluid. Colloids Surf B 135:201–208Google Scholar
  37. 37.
    Liu X, Wang R (2017) Effective removal of hydrogen sulfide using 4A molecular sieve zeolite synthesized from attapulgite. J Hazard Mater 326:157–164Google Scholar
  38. 38.
    Chao C, Park DW, Ahn WS (2014) CO2 capture using zeolite 13X prepared from bentonite. Appl Surf Sci 292:63–67Google Scholar
  39. 39.
    Ferreira L, Fonseca AM, Botelho G, Almeida-Aguiar C, Neves IC (2012) Antimicrobial activity of faujasite zeolites doped with silver. Microporous Mesoporous Mater 160(160):126–132Google Scholar
  40. 40.
    Krishnani KK, Yu Z, Xiong L, Yan Y, Boopathy R, Mulchandani A (2012) Bactericidal and ammonia removal activity of silver ion-exchanged zeolite. Bioresour Technol 117:86–91Google Scholar
  41. 41.
    Fox S, Wilkinson TS, Wheatley PS, Xiao B, Morris RE, Sutherland A, Simpson AJ, Barlow PG, Butler AR, Megson IL (2010) NO-loaded Zn-exchanged zeolite materials: a potential bifunctional anti-bacterial strategy. Acta Biomater 6(4):1515–1521Google Scholar
  42. 42.
    Yao G, Lei J, Zhang W, Yu C, Sun Z, Zheng S, Komarneni S (2019) Antimicrobial activity of X zeolite exchanged with Cu2+ and Zn2+ on Escherichia coli and Staphylococcus aureus. Environ Sci Pollut Res 26:2782–2793Google Scholar
  43. 43.
    Chen Y, Zhang Y, Liu J, Zhang H, Wang K (2012) Preparation and antibacterial property of polyethersulfone ultrafiltration hybrid membrane containing halloysite nanotubes loaded with copper ions. Chem Eng J 210(6):298–308Google Scholar
  44. 44.
    Stafford SL, Bokil NJ, Achard MES, Ronan K, Schembri MA, Mcewan AG, Sweet MJ (2013) Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper. Biosci Rep 33(4):541–554Google Scholar
  45. 45.
    Zhao C, Liu B, Bi X, Liu D, Pan C, Wang L, Pang Y (2016) A novel flavonoid-based bioprobe for intracellular recognition of Cu2+ and its complex with Cu2+ for secondary sensing of pyrophosphate. Sens Actuators B Chem 229:131–137Google Scholar
  46. 46.
    Radovanović Ž, Jokić B, Veljović D, Dimitrijević S, Kojić V, Petrović R, Janaćković D (2014) Antimicrobial activity and biocompatibility of Ag+- and Cu2+-doped biphasic hydroxyapatite/α-tricalcium phosphate obtained from hydrothermally synthesized Ag+- and Cu2+-doped hydroxyapatite. Appl Surf Sci 307:513–519Google Scholar
  47. 47.
    Boschetto DL, Lerin L, Cansian R, Pergher SBC, Luccio MD (2012) Preparation and antimicrobial activity of polyethylene composite films with silver exchanged zeolite-Y. Chem Eng J 204–206:210–216Google Scholar
  48. 48.
    Shi H, Fu L, Xue L (2013) Fabrication and characterization of antibacterial PVDF hollow fibre membrane by doping Ag-loaded zeolites. J Membr Sci 437(12):205–215Google Scholar
  49. 49.
    Liao C, Ping Y, Zhao J, Wang L, Luo Y (2011) Preparation and characterization of NaY/PVDF hybrid ultrafiltration membranes containing silver ions as antibacterial materials. Desalination 272(1):59–65Google Scholar
  50. 50.
    Yao G, Lei J, Zhang X, Sun Z, Zheng S (2018) One-step hydrothermal synthesis of zeolite X powder from natural low-grade diatomite. Materials 11(6):906Google Scholar
  51. 51.
    Zhang Y, Zhong S, Zhang M, Lin Y (2009) Antibacterial activity of silver-loaded zeolite a prepared by a fast microwave-loading method. J Mater Sci 44(2):457–462.  https://doi.org/10.1007/s10853-008-3129-5 Google Scholar
  52. 52.
    Hanim SAM, Malek NANN, Ibrahim Z (2016) Amine-functionalized, silver-exchanged zeolite NaY: preparation, characterization and antibacterial activity. Appl Surf Sci 360:121–130Google Scholar
  53. 53.
    Chick H (1908) An investigation of the laws of disinfection. J Hyg 8(01):92–158Google Scholar
  54. 54.
    Zhu L, Dai J, Chen L, Chen J, Na H, Zhu J (2017) Design and fabrication of imidazolium ion-immobilized electrospun polyurethane membranes with antibacterial activity. J Mater Sci 52(5):2473–2483.  https://doi.org/10.1007/s10853-016-0542-z Google Scholar
  55. 55.
    Lemire JA, Harrison JJ, Turner RJ (2013) Antimicrobial activity of metals: mechanisms, molecular targets and applications. Nat Rev Microbiol 11(6):371–384Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Chemical and Environmental EngineeringChina University of Mining and Technology (Beijing)BeijingPeople’s Republic of China
  2. 2.Beijing Key Laboratory of Clothing Materials R&D and Assessment, Beijing Engineering Research Center of Textile NanofiberSchool of Materials, Design and EngineeringBeijingPeople’s Republic of China

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