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Synergistic antioxidant activity and anticancer effect of green tea catechin stabilized on nanoscale cyclodextrin-based metal–organic frameworks

  • Fei KeEmail author
  • Mengran Zhang
  • Nianqiao Qin
  • Gege Zhao
  • Jun Chu
  • Xiaochun WanEmail author
Materials for life sciences
  • 34 Downloads

Abstract

Green tea catechins have received significant attention due to their potent antioxidant activity as well as diverse biological properties. Stabilizing and protecting catechins from degradation is very important but challenging. In this work, a nanosized edible γ-cyclodextrin-based metal–organic framework (CD-MOF) was designed and fabricated by a facile vapor diffusion route and applied for the encapsulation of a model green tea catechin, (-)-epigallocatechin gallate (EGCG) for the first time. Downsizing CD-MOF to the nanoscale is a suitable method to tackle down new applications. Significantly, the antioxidant activity results show that the CD-MOF-EGCG can remarkably enhance the antioxidant activity in alkaline solutions, as compared to that of free EGCG. Furthermore, the prepared CD-MOF-EGCG showed strong cancer cell growth inhibitory effects on C6 cells as confirmed by the cell viability assay. This work demonstrates that such safe and nontoxic nanoscale CD-MOF-based porous materials hold great promise for applications in the field of stabilization of catechins for biomedical applications.

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (NSFC, 21501003), Natural Science Foundation of Anhui Province (1608085QB27), China Postdoctoral Science Foundation funded project (2015M581973), the Scientific Research Foundation of Anhui Agricultural University (GrantNo. yj2015-26), and Provincial Undergraduate Training Programs for Innovation and Entrepreneurship of Anhui Agriculture University(201710364054).

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Tea Plant Biology and Utilization and Department of Applied ChemistryAnhui Agricultural UniversityHefeiPeople’s Republic of China
  2. 2.Key Laboratory of Xin’an Medicine, Ministry of EducationAnhui University of Traditional Chinese MedicineHefeiPeople’s Republic of China

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