Journal of Materials Science

, Volume 54, Issue 13, pp 9689–9706 | Cite as

A doxorubicin and vincristine drug release system based on magnetic PLGA microspheres prepared by coaxial electrospray

  • Yajun Tang
  • He Zhao
  • Jihang Yao
  • Zhenhua Zhu
  • Dahui Sun
  • Mei ZhangEmail author
Materials for life sciences


In this study, we demonstrated a novel doxorubicin and vincristine-loaded PLGA magnetic microspheres prepared by coaxial electrospray, as a drug delivery system for osteosarcoma treatment. The results showed that microspheres had an minimum mean diameter of 0.32 ± 0.25 μm and exhibited a spherical shape. The particle size distribution changed obviously with the different dosing ways. The entrapment efficiency was found to be 65.72, 73.6 and 74.14% for different microspheres. In vitro degradation research showed that circular pores appeared gradually on the surface of particles with the increase in time, which accelerated the degradation of microspheres. CCK-8 test showed that the Fe3O4@PLGA microspheres without drug loading had almost no side effects, the cytotoxicity of Fe3O4@P/(V + D), Fe3O4@(P + D)/V and Fe3O4@(P + V)/D microspheres increased in turn, and Fe3O4@(P + V)/D microspheres with minimum particle size could significantly arrest the growth of osteosarcoma saos-2 cells. Therefore, the drug-loaded magnetic microspheres have good killing effect on osteosarcoma cell lines, which can be used as an ideal targeting treatment for postoperative adjuvant therapy of osteosarcoma.



The work was supported by Jilin Province Health Project 2018 (3D517EB73428) and Key Project of Science and Technology Development Plan, Jilin Province of China (20170204042GX).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10853_2019_3575_MOESM1_ESM.docx (1.3 mb)
Supplementary material 1 (DOCX 1283 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Alan G. MacDiarmid Laboratory, College of ChemistryJilin UniversityChangchunPeople’s Republic of China
  2. 2.Norman Bethune First Hospital, Jilin UniversityChangchunPeople’s Republic of China

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