Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release
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We constructed a novel stimuli-responsive system, MSNPs 1, based on mechanized silica nanoparticles, in which mesoporous silica nanoparticles (MSNs) acted as nanocontainers to load cargo, and supramolecular switches consisting of hydrazone bond, azobenzene and α-cyclodextrin (α-CD) realized the controlled release of cargo molecules from MSNPs 1. In neutral solution and without UV light irradiation, the azobenzene component on functional stalks was in trans form, and combined with α-CD to block the mesoporous channels and prevent the cargo from escaping. Upon adjusting the solution pH to acid range, the acid-sensitive hydrazone bonds rapidly hydrolyzed, resulting in the disconnection between pseudorotaxanes and MSNs. The encapsulated cargo molecules were released simultaneously from MSNPs 1 due to the removal of supramolecular switches. On the other hand, when the neutral solution was irradiated with UV light at 365 nm, trans-azobenzene converted to cis, disassociating with α-CD to activate the switches and release the cargo. The unique acid- and light-triggered controlled release properties of MSNPs 1 have potential application in various fields. In this manuscript, doxorubicin (DOX) was selected to be stored in MSNPs 1, due to the anticancer property. MCF-7 human breast cancer cells could phagocytose DOX-loaded MSNPs 1 easily, and the released DOX showed the killing effect.
The authors thank the Fundamental Research Funds for the Central University, Grant Nos. 30915012207 and 30918012201; the National Nature Science Foundation of China, Grant Nos. U1737105 and 51672133; the National Science Foundation of Jiangsu Province, Grant No. BK20161496; the QingLan Project, Jiangsu Province, China; a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
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Conflict of interest
The authors declare that they have no conflict of interest.
- 12.Lai CY, Trewyn BG, Jeftinija DM, Jeftinjia K, Xu S, Jeftinija S, Lin VSY (2003) A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. J Am Chem Soc 125:4451–4459CrossRefGoogle Scholar
- 31.Miyata K, Oba M, Nakanishi M, Fukushima S, Yamasaki Y, Koyama H, Nishiyama N, Kataoka K (2008) Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J Am Chem Soc 130:16287–16294CrossRefGoogle Scholar