Polymer microsphere for water-soluble drug delivery via carbon dot-stabilizing W/O emulsion
- 15 Downloads
Emulsions, usually oil-in-water emulsions, have been widely applied to the preparation of hydrophobic drug carriers. However, the synthesis of safe, biocompatible and high-performance carriers for water-soluble drugs remains a challenge. So polyacrylamide (PAM) microspheres stabilized by carbon dots (CDs) were fabricated via a water-in-oil Pickering emulsion without the use of any surfactant. The PAM/CD microspheres were spherical with an even distribution of the CDs on their surfaces. The size of the microspheres can be controlled by changing the amount of CDs, which also influenced the drug loading properties. The hydrophilic chemotherapy drug, 5-fluorouracil (5-FU), was successfully loaded into the PAM/CD microspheres through incubation. The encapsulation efficiencies ranged from 68 to 82% with a maximum drug loading of 48%. The 5-FU release profiles depended on the concentration of the drug incubation solution, the concentration of the CD solution and the pH of the drug release environment. The release of 5-FU was relatively steady for the first 12 h and followed non-Fickian diffusion kinetics. This synthetic approach could be extrapolated to loading of other water-soluble drugs into hydrophilic polymers.
This work was supported by the National Science Foundation of China (51573126).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 5.Kokil GR, Veedu RN, Le BT, Ramm GA, Parekh HS (2018) Self-assembling asymmetric peptide-dendrimer micelles—a platform for effective and versatile in vitro nucleic acid delivery. Sci Rep UK 8(4832):1–16Google Scholar
- 23.Amalvy JI, Unali GF, Li Y, Granger-Bevan S, Armes SP, Binks BP et al (2004) Synthesis of sterically stabilized polystyrene latex particles using cationic block copolymers and macromonomers and their application as stimulus-responsive particulate emulsifiers for oil-in-water emulsions. Langmuir 20:4345–4354CrossRefGoogle Scholar
- 43.Yang J, Gao J, Wang X, Mei S, Zhao R, Hao C et al (2017) Polyacrylamide hydrogel as a template in situ synthesis of CdS nanoparticles with high photocatalytic activity and photostability. J Nanopart Res 19(350):1–13Google Scholar
- 49.Beamson G, Briggs D (1992) High resolution XPS of organic polymers: the scienta ESCA300 database. Wiley, New YorkGoogle Scholar
- 52.Wang D, Liu J, Chen J, Dai L (2016) Surface functionalization of carbon dots with polyhedral oligomeric silsesquioxane (POSS) for multifunctional applications. Adv Mater Interfaces 3(1500439):1–6Google Scholar
- 53.Maaoui H, Teodoresu F, Wang Q, Pan G, Addad A, Chtourou R et al (2016) Non-enzymatic glucose sensing using carbon quantum dots decorated with copper oxide nanoparticles. Sens Basel 16(1720):1–10Google Scholar
- 60.Bravo SA, Lamas MC, Salamon CJ (2002) In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices. J Pharm Pharm Sci 5(3):213–219Google Scholar