Systematic investigation and in vitro biocompatibility studies on implantable magnetic nanocomposites for hyperthermia treatment of osteoarthritic knee joints
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The inefficacy of the currently used treatment modalities for osteoarthritis has elicited considerable research interest in the exploration of alternative methods. Hyperthermia treatment, generally used in the case of lesions, maybe considered as a viable solution owing to the economic and ergonomic factors involved. In the present study, Cr-doped Fe2O3 embedded in PVDF matrix is proposed as the biocompatible magnetic-dielectric composite to provide thermo-regulated prolonged treatment. A systematic study was carried out to characterize the physical properties of the prepared formulation. Further, cellular uptake studies were done to ensure bioviability. Finite element method studies using COMSOL were used to simulate the hyperthermia treatment of osteoarthritic knee joint. The approach proposed here may be used further to develop a novel class of therapeutic devices for the treatment of osteoarthritis.
KeywordsFe2O3 Nanoparticles Magnetic Composite Hyperthermia Treatment Nitrate Nonahydrate Prepared Formulation
The authors would like to acknowledge Dr. Shabina Khanam, Chemical Engineering Department, Indian Institute of Technology Roorkee for assisting in the usage of COMSOL. SS like to acknowledge Prof. Max Shtein from University of Michigan, Ann Arbor, USA for useful discussion. For financial support, authors would like to thank Sponsored Research and Industrial Consultancy, IIT Roorkee under Grant SRIC-CONSL-000-414 dt. 09.09.2015. SS like to acknowledge Faculty Initiation Grant from IIT Roorkee.
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Conflict of interest
All authors would like to declare no conflicts of interest.
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