Journal of Materials Science

, Volume 46, Issue 20, pp 6758–6765 | Cite as

Sacrificial functional polystyrene template to prepare chitosan nanocapsules and in vitro drug release properties

  • Weijun LiuEmail author
  • Guihua Chen
  • Guanghong He
  • Zhicai He
  • Zhang Qian


In this study, biocompatible and biodegradable chitosan (CS) nanocapsules are successfully prepared in abundant and easily using carboxyl-functionalized polystyrene (PS) as sacrificial template and cross-linked CS with glutaraldehyde as the shell. First, the monodisperse functionalized PS templates be about 200 nm are made by emulsifier-free emulsion polymerization. Second, nanocapsules are accomplished by fabricating on the basis of chemical cross-linking on the surface of the PS template and removing the core via tetrahydrofuran. The templates and nanocapsules were characterized by FT–IR, 1H NMR, FESEM, and TEM. All the results confirmed that the nanocapsules are accomplished via this method. By dissolution of ibuprofen in the chloroform droplets when prepare the carboxyl-functionalized PS, drug-loaded nanocapsules are also fabricated. It is found that the loaded drug can be released again in a sustained manner for up to 80 h. The nanocapsules walls have a prominent effect in slowing down the drug release rate.


Chitosan Drug Release Ibuprofen Hollow Microsphere Ibuprofen Release 



We greatly appreciate the help from Central Laboratory of Analysis and Structure Research in University of Science and Technology of China (USTC). This study is financially supported the National Science Foundation for Post-doctoral Scientists of China (no. 20100471000).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Weijun Liu
    • 1
    Email author
  • Guihua Chen
    • 1
  • Guanghong He
    • 1
  • Zhicai He
    • 1
  • Zhang Qian
    • 2
  1. 1.Department of Polymer Science and Engineering, School of Pharmaceutical and Chemical EngineeringTaizhou UniversityLinhaiPeople’s Republic of China
  2. 2.Department of Polymer Science and EngineeringAnhui UniversityHefeiPeople’s Republic of China

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