Journal of Materials Science

, Volume 46, Issue 18, pp 5959–5968 | Cite as

Synthesis and applications of fluorescent-magnetic-bifunctional dansylated Fe3O4@SiO2 nanoparticles

  • Gang Liu
  • Huixia WuEmail author
  • Haoran Zheng
  • Lihui Tang
  • He Hu
  • Hong Yang
  • Shiping YangEmail author


Bifunctional magnetic-luminescent dansylated Fe3O4@SiO2 (Fe3O4@SiO2-DNS) nanoparticles were fabricated by the nucleophilic substitution of dansyl chloride with primary amines of aminosilane-modified Fe3O4@SiO2 core–shell nanostructures. The morphology and properties of the resultant Fe3O4@SiO2-DNS nanoparticles were investigated by transmission electron microscopy, FT–IR spectra, UV–vis spectra, photoluminescence spectra, and vibrating sample magnetometry. The Fe3O4@SiO2-DNS nanocomposites exhibit superparamagnetic behavior at room temperature, and can emit strong green light under the excitation of UV light. They show very low cytotoxicity against HeLa cells and negligible hemolysis activity. The T2 relaxivity of Fe3O4@SiO2-DNS in water was determined to be 114.6 Fe mM−1 s−1. Magnetic resonance (MR) imaging analysis coupled with confocal microscopy shows that Fe3O4@SiO2-DNS can be uptaken by the cancer cells effectively. All these positive attributes make Fe3O4@SiO2-DNS a promising candidate for both MR and fluorescent imaging applications.


Fe3O4 Nanoparticles Hemolytic Activity Dansyl HeLa Cell Line Hemolysis Assay 



This study is supported by the National Natural Science Foundation of China (Grant no. 50972092, 20971086), the Science and Technology Commission of Shanghai Municipality (065212050, S30406), Special Foundation of China Postdoctoral Science Foundation (201003282), the Shanghai Key Laboratory of the Rare Earth Functional Materials (07dz22303), the Shanghai Municipal Education Commission (10ZZ84), Leading Academic Discipline Project of Shanghai Normal University (DZL806), and the Key Subject of Education Ministry of China (210075).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.The Key Laboratory of Resource Chemistry of Ministry of Education, College of Life and Environmental ScienceShanghai Normal UniversityShanghaiPeople’s Republic of China

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