Preparation, characterization, and blood compatibility of polylactide-based phospholipid polymer
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l-α-glycerophosphorylcholine (GPC) was obtained by hydrolysis of lecithin extracted from eggs. FT-IR and 1H-NMR analysis indicated a successful preparation of GPC. Polylactide-based phospholipid polymer (PLLA-PC) was synthesized by ring-opening polymerization of l-lactide in the presence of GPC to improve the cell/material interfacial reaction of PLLA for tissue engineering applications. The yield of the reaction strongly depended on the reaction time. Values above 80% were obtained which are much higher than those reported in literature. Copolymers with the largest molecular weights were obtained at 122 °C for 48 h. The properties and biocompatibility of the PLLA-PC copolymers were characterized. Surface rearrangement was detected due to the dynamic molecular motion according to X-ray photoelectron spectroscopy data. Besides, increase in hydrophilicity and decreases in fibrinogen adsorption and platelet adhesion were observed due to the hydrophilic phosphorylcholine moieties in the copolymer.
KeywordsLecithin PLLA Platelet Adhesion Copolymer Film PDLA
This study was financially supported by NSFC (No. 50473025) and International S&T Cooperation Program of China (No. 2006DFA53470). The authors would like to thank Prof. Chen Hong from Wuhan University of Technology for fibrinogen adsorption tests.