Advertisement

Journal of Materials Science

, Volume 44, Issue 23, pp 6317–6324 | Cite as

Preparation, characterization, and blood compatibility of polylactide-based phospholipid polymer

  • Niancao Chen
  • Yuanwei Chen
  • Lijian Wang
  • Xianglin LuoEmail author
  • Juan Luo
  • Bin Wang
Article

Abstract

l-α-glycerophosphorylcholine (GPC) was obtained by hydrolysis of lecithin extracted from eggs. FT-IR and 1H-NMR analysis indicated a successful preparation of GPC. Polylactide-based phospholipid polymer (PLLA-PC) was synthesized by ring-opening polymerization of l-lactide in the presence of GPC to improve the cell/material interfacial reaction of PLLA for tissue engineering applications. The yield of the reaction strongly depended on the reaction time. Values above 80% were obtained which are much higher than those reported in literature. Copolymers with the largest molecular weights were obtained at 122 °C for 48 h. The properties and biocompatibility of the PLLA-PC copolymers were characterized. Surface rearrangement was detected due to the dynamic molecular motion according to X-ray photoelectron spectroscopy data. Besides, increase in hydrophilicity and decreases in fibrinogen adsorption and platelet adhesion were observed due to the hydrophilic phosphorylcholine moieties in the copolymer.

Keywords

Lecithin PLLA Platelet Adhesion Copolymer Film PDLA 

Notes

Acknowledgement

This study was financially supported by NSFC (No. 50473025) and International S&T Cooperation Program of China (No. 2006DFA53470). The authors would like to thank Prof. Chen Hong from Wuhan University of Technology for fibrinogen adsorption tests.

References

  1. 1.
    Langer R, Vacanti JP (1993) Science 260:920CrossRefGoogle Scholar
  2. 2.
    Butler DL, Hunter SA, Chokalingam K, Cordray MJ, Shearn J, Juncosa-Melvin N, Nirmalanandhan S, Jain A (2009) Tissue Eng A 15:741CrossRefGoogle Scholar
  3. 3.
    Zhang JH, Kissounko DA, Lee SE, Gellman SH, Stahl SS (2009) J Am Chem Soc 131:1589CrossRefGoogle Scholar
  4. 4.
    van Kooten TG, Spijker HT, Busscher HJ (2004) Biomaterials 25:1735CrossRefGoogle Scholar
  5. 5.
    Hersel U, Dahmen C, Kessler H (2003) Biomaterials 24:4385CrossRefGoogle Scholar
  6. 6.
    Hayward JA, Chapman D (1984) Biomaterials 5:135CrossRefGoogle Scholar
  7. 7.
    Kono K, Ito Y, Kimura S, Imanishi Y (1989) Biomaterials 10:455CrossRefGoogle Scholar
  8. 8.
    Ishihara K, Aragaki R, Ueda T, Watanabe A, Nakabayashi NJ (1990) Biomed Mater Res 24:1069CrossRefGoogle Scholar
  9. 9.
    Iwasaki Y, Kurita K, Ishihara K, Nakabayashi NJ (1994) Biomater Sci Polym Edn 6:447CrossRefGoogle Scholar
  10. 10.
    Marra KG, Winger TM, Hanson SR, Chaikof EL (1997) Macromolecules 30:6483CrossRefGoogle Scholar
  11. 11.
    vander Heiden AP, Willemes GM, Lindhout T, Pijpers AP, Koole LH (1998) J Biomed Mater Res 40:195CrossRefGoogle Scholar
  12. 12.
    Matsuda T, Kaneko M, Ge S (2003) Biomaterials 24:4507CrossRefGoogle Scholar
  13. 13.
    Watanabe J, Ishihara K (2003) Artif Organs 27:242CrossRefGoogle Scholar
  14. 14.
    Watanabe J, Eriguchi T, Ishihara K (2002) Biomacromolecules 3:1375CrossRefGoogle Scholar
  15. 15.
    Iwasaki Y, Tojo Y, Kurosaki T, Nakabayashi N (2003) J Biomed Mater Res 65:164CrossRefGoogle Scholar
  16. 16.
    Regen S, Singh A, Oehme G, Singh M (1982) J Am Chem Soc 104:791CrossRefGoogle Scholar
  17. 17.
    Watanabe J, Eriguchi T, Ishihara K (2002) Biomacromolecules 3:1109CrossRefGoogle Scholar
  18. 18.
    Watanabe J, Nederberg F, Atthoff B, Bowden T, Hilborn J, Ishihara K (2007) Mater Sci Eng 27:227CrossRefGoogle Scholar
  19. 19.
    Slack SM, Horbett TA (1992) J Biomed Mater Res 26:1633CrossRefGoogle Scholar
  20. 20.
    Jen MY, Hao TL (2001) J Membr Sci 187:159CrossRefGoogle Scholar
  21. 21.
    Rodrigues SN, Gonçalves IC, Martins MCL, Barbosa MA, Ratner BD (2006) Biomaterials 27:5357CrossRefGoogle Scholar
  22. 22.
    Rodrigues SN, Gonçalves IC, Martins MCL, Barbosa MA, Ratner BD (2005) Biomaterials 26:7367CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Niancao Chen
    • 1
  • Yuanwei Chen
    • 1
  • Lijian Wang
    • 1
  • Xianglin Luo
    • 2
    Email author
  • Juan Luo
    • 2
  • Bin Wang
    • 1
  1. 1.Department of Biomaterials and Artificial Organs, College of Polymer Science and EngineeringSichuan UniversityChengduPeople’s Republic of China
  2. 2.Department of Biomaterials and Artificial Organs, College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials and Engineering of ChinaSichuan UniversityChengduPeople’s Republic of China

Personalised recommendations