Journal of Materials Science

, Volume 44, Issue 3, pp 828–834 | Cite as

Study of the cohesion of TTCP/DCPA phosphate cement through evolution of cohesion time and remaining percentage

  • Gaoxiang Chen
  • Wanwan Li
  • Xiaoming Yu
  • Kang SunEmail author


Recent studies have revealed that the cohesion of calcium phosphate cement (CPC) might be a key property to ensure a safe and reliable clinical use of CPCs. Our study focused on the evolution of cohesion time and remaining percentage of TTCP/DCPA phosphate cement with changing factors in order to uncover the dependence of the cohesion of CPC on setting solutions and incubation liquids. Several factors were considered, including incubation liquids, concentration of setting solutions, powder to liquid (P/L) ratio, and polymer additive in setting solution. Results showed that the total ion osmotic pressure of both setting solutions and incubation solutions had significant influence on cohesion. Using physiological saline and simulation body fluid as incubation liquids indicated that the species of ions sometimes had much more profound effect on cohesion. Results of varying P/L ratios showed a great dependence on setting liquids, and a spot of water-soluble polymer additive was proved to be positive for cohesion.


Dextran Setting Solution Simulation Body Fluid Calcium Phosphate Cement Cohesion Time 



We thank Shanghai Sunny New Technology Development Co., Ltd. for their financial support.


  1. 1.
    Wei S, Liu CS, Gu YY (1998) J Chin Ceram Soc 26:129Google Scholar
  2. 2.
    Gruninger SE, Siew C, Chow LC (1984) J Dent Res 63:200Google Scholar
  3. 3.
    Fuhkase Y, Eanes ED, Takag S et al (1990) J Dent Res 69:1852CrossRefGoogle Scholar
  4. 4.
    Ishikawa K, Eanes ED (1993) J Dent Res 72:474CrossRefGoogle Scholar
  5. 5.
    Chohayeb AA, Chow LC, Tsaknis P (1987) J Endod 13:384CrossRefGoogle Scholar
  6. 6.
    Liu C, Shen W, Gu Y, Hu L (1997) J Biomed Mater Res 35:75CrossRefGoogle Scholar
  7. 7.
    Bohner M, Doebelin N, Baroud G (2006) Eur Cell Mater 12:26CrossRefGoogle Scholar
  8. 8.
    Bohner M, Gbureck U, Barralet JE (2005) Biomaterials 26:6423CrossRefGoogle Scholar
  9. 9.
    Bernards CM, Chapman JR, Mirza SK (2005) In: Proceedings of the 50th annual meeting of the orthopaedic research society (ORS), San Francisco, p 254Google Scholar
  10. 10.
    Axen N, Ahnfelt NO, Persson T (2004) In: Proceedings of the 9th annual meeting “ceramics, cells and tissues”, FaenzaGoogle Scholar
  11. 11.
    Hiemenz PC (1986) Principles of colloid and surface chemistry. Dekker, New YorkGoogle Scholar
  12. 12.
    Fernandez E, Boltong MG, Ginebra MP (1996) J Mater Sci Lett 15:1004CrossRefGoogle Scholar
  13. 13.
    Ishikawa K, Miyamoto Y, Kon M (1995) Biomaterials 16:527CrossRefGoogle Scholar
  14. 14.
    Cherng A, Takagi S, Chow LC (1997) J Biomed Mater Res 35:273CrossRefGoogle Scholar
  15. 15.
    Khairoun I, Driessens FCM, Boltong MG (1999) Biomaterials 20:393CrossRefGoogle Scholar
  16. 16.
    Kokubo T, Takadama H (2006) Biomaterials 27:2907CrossRefGoogle Scholar
  17. 17.
    Ishikawa K, Takechi M, Ueyama Y, Suzuki K, Nagayama M, Matsumura T (1999) J Biomed Mater Res 44:322CrossRefGoogle Scholar
  18. 18.
    Liu CH, Shao HF, Chen FY, Zheng HY (2006) Biomaterials 27:5003CrossRefGoogle Scholar
  19. 19.
    Rammelt S, Neumann M, Hanisch U (2005) J Biomed Mater Res 73:284CrossRefGoogle Scholar
  20. 20.
    Barralet JE (2003) Adv Mater 15:2091CrossRefGoogle Scholar
  21. 21.
    Bigi A, Bracci B, Panzavolta S (2004) Biomaterials 25:2893CrossRefGoogle Scholar
  22. 22.
    Sawamura T, Hattori M, Okuyama M et al (2004) Key Eng Mater 254:209Google Scholar
  23. 23.
    Ishikawa K, Miyamoto Y, Takechi M, Toh T, Kon M, Nagayama M, Asaoka K (1997) J Biomed Mater Res 36:393CrossRefGoogle Scholar
  24. 24.
    Bohner M, Merkle HP, Vanlanduyt P, Trophardy G, Lemaitre J (2000) J Mater Sci Mater Med 11:111CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Gaoxiang Chen
    • 1
  • Wanwan Li
    • 1
  • Xiaoming Yu
    • 1
  • Kang Sun
    • 1
    Email author
  1. 1.State Key Lab of Metal Matrix CompositesShanghai Jiaotong UniversityShanghaiPeople’s Republic of China

Personalised recommendations