Journal of Materials Science

, Volume 44, Issue 9, pp 2264–2270 | Cite as

Morphological changes in biomimetically synthesized hydroxyapatite and silver nanoparticles for medical applications

  • Tanmay Bera
  • P. Ramachandrarao
Festschrift in honour of Prof T R Anantharaman on the occasion of his 80th birthday


A precise control of morphology, which plays a significant role towards the application of materials, can be achieved by studying the effects of macromolecules as nucleation templates for minerals in a biomineralization process. The present investigation aims to understand such effects on medically important materials. Thus, Silver (Ag) and Calcium hydroxyapatite [Ca10(PO4)6(OH)2] were synthesized in both biopolymer (gelatin) and synthetic polymer (PVA) media, with aqueous medium as the control to portray a collage of how the interface between the macromolecule and the mineral controls the final morphology of the materials. It was also observed that the change of morphology of the products does influence their performances in specific applications like antibacterial property of the nanoparticles of silver was found to the best when synthesized in aqueous media. Thus, we consider that the organic–inorganic interaction to be of vital significance in the synthesis of complex shapes and sizes of nanoparticles for important applications.


Gelatin Hydroxyapatite Silver Nanoparticles Silver Nitrate Solution Hydroxyapatite Crystal 



We sincerely acknowledge the help provided by Dr Vivek A.N. and Prof. S.K. Saraf of Department of Orthopedics; Mr. S. Shrivastava and Dr. D. Dash of Department of Biochemistry Institute of Medical Sciences (IMS), Banaras Hindu University (BHU) for their generous supports and help and Prof. J.V. Medicherla, Molecular Biology Unit, IMS, BHU for providing with laboratory space to carry out the experiments. We are thankful to Prof. S. Lele and Dr. R.K. Mandal of B.H.U. for their valuable discussions and encouragement.


  1. 1.
    Mann S (2001) Biomineralization: principles and concepts in bioinorganic materials chemistry. Oxford University Press, OxfordGoogle Scholar
  2. 2.
    Gilbert PUPA, Abrecht M, Frazer BH (2005) Rev Mineral Geochem 59:157. doi: CrossRefGoogle Scholar
  3. 3.
    Yang Y, Chen X, Shao Z, Zhou P, Porter D, Kinght DP, Vollrath F (2005) Adv Mater 17:84. doi: CrossRefGoogle Scholar
  4. 4.
    Smith BL, Schaffer TE, Viani M, Thompson JB, Frederick NA, Kindt J, Belcher AM, Stucky GD, Morse DE, Hansma PK (1999) Nature 399:761. doi: CrossRefGoogle Scholar
  5. 5.
    Klauss–Joerger T, Joerger R, Olsson E, Granquist CG (2001) Trends Biotechnol 19:15. doi: CrossRefGoogle Scholar
  6. 6.
    Ramachandrarao P (2003) Sādhnā 28:657. doi: CrossRefGoogle Scholar
  7. 7.
    Jackson A, Vincent JE, Turner RM (1998) P Roy Soc B-Biol Sci 234:415Google Scholar
  8. 8.
    Anderson JC, Eriksson C (1970) Nature 227:491. doi: CrossRefGoogle Scholar
  9. 9.
    Almqvist N, Thomson NH, Smith BL, Stucky GD, Morse DE, Hansma PK (1999) Mat Sci Eng C 7:37. doi: CrossRefGoogle Scholar
  10. 10.
    Mann S (1993) Nature 365:499. doi: CrossRefGoogle Scholar
  11. 11.
    Mann S, Heywood BR, Rajam S, Birchall JD (1988) Nature 334:692. doi: CrossRefGoogle Scholar
  12. 12.
    Berman A, Addadi L, Kvick A, Leiserowitz L, Nelson M, Weiner S (1990) Science 250:664. doi: CrossRefGoogle Scholar
  13. 13.
    Bera T, Ramachandrarao P (2007) J Bionic Eng 4:133. doi: CrossRefGoogle Scholar
  14. 14.
    Shrivastava S, Bera T, Roy A, Singh G, Ramachandrarao P, Dash D (2007) Nanotechnology 18:225103. doi: CrossRefGoogle Scholar
  15. 15.
    Bera T, Vivek AN, Saraf SK, Ramachandrarao P (2008) Biomed Mater 3:025001. doi: CrossRefGoogle Scholar
  16. 16.
    Glimcher MJ (1984) Philos T Roy Soc B 304:479. doi: CrossRefGoogle Scholar
  17. 17.
    Yu D, Lin W, Lin C, Chang L, Yang M (2007) Mater Chem Phys 101:93. doi: CrossRefGoogle Scholar
  18. 18.
    Mann S (ed) (1996) Biomimetic materials chemistry. VCH, NewYorkGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of Metallurgical EngineeringIT-BHUVaranasiIndia
  2. 2.International Advanced Research Centre for Powder Metallurgy and other New Materials (ARCI)Balapur, HyderabadIndia

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