QCM sensors coated with calix[4]arenes bearing sensitive chiral moieties for chiral discrimination of 1-phenylethylamine enantiomers

  • Egemen Ozcelik
  • Farabi Temel
  • Serkan Erdemir
  • Begum Tabakci
  • Mustafa TabakciEmail author
Original Article


This article describes the enantiomeric discrimination properties of new chiral calix[4]arene derivatives bearing (S)-/(R)-1-phenylethylamine moieties (5a and 5b, respectively) towards the 1-phenylethylamine enantiomers on QCM surface. Initial experiments demonstrated that the 5b coated QCM sensor was the most effective sensing material for enantiomeric discrimination of (R)-/(S)-1-phenylethylamine by exhibiting much more sensing ability towards (R)-enantiomer than (S)-enantiomer. Sensitivity, detection limit and time constant of the 5b coated QCM sensor has been were calculated as 0.082 Hz/µM, 2.7 µM, and 319.2 s, respectively. Additionally, effects of calixarene content and different coating technique on enantiomeric discrimination, and Langmuir and Freundlich isotherms of the sensing results also were studied. As a result, it has been demonstrated that the coating of QCM sensor with a chiral calix[4]arene (5b) having (S)-1-phenylethylamine moieties provides substantially enantiomeric discrimination of 1-phenylethylamine enantiomers.


1-Phenylethylamine Organic coatings Calixarene Enantiomeric discrimination Quartz crystal microbalance sensor 



We thank the Technical Research Council of Turkey (TUBITAK—Grant No. 115Z249) and the Research Foundation of the Selçuk University (SUBAP-Grant No. 16401003), Konya, Turkey and for financial support of this work produced from Egemen Ozcelik’s M.Sc. Thesis.

Supplementary material

10847_2019_892_MOESM1_ESM.docx (975 kb)
Supplementary material 1 (DOCX 974 KB)


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Copyright information

© Springer Nature B.V. 2019
corrected publication 2019

Authors and Affiliations

  • Egemen Ozcelik
    • 1
    • 2
  • Farabi Temel
    • 1
    • 2
  • Serkan Erdemir
    • 3
  • Begum Tabakci
    • 3
  • Mustafa Tabakci
    • 1
    • 2
    Email author
  1. 1.Department of Chemical EngineeringKonya Technical UniversityKonyaTurkey
  2. 2.Department of Chemical EngineeringSelçuk UniversityKonyaTurkey
  3. 3.Department of ChemistrySelçuk UniversityKonyaTurkey

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