CABANA trial: “beauty is in the eye of the beholder”
The CABANA trial reported that catheter ablation, when compared with drug therapy, did not significantly reduce the primary composite end point of death, disabling stroke, serious bleeding, or cardiac arrest in patients with atrial fibrillation. Despite multiple limitations in study design, the CABANA trial still confirmed that catheter ablation of atrial fibrillation led to clinically important and significant improvements in quality of life at 12 months without increasing the risk of complications.
KeywordsAblation Atrila fibrillation Mortality Outcomes
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Packer DL, Mark DB, Robb RA, Monahan KH, Bahnson TD, Poole JE, et al. Effect of catheter ablation vs antiarrhythmic drug therapy on mortality, stroke, bleeding, and cardiac arrest among patients with atrial fibrillation: the CABANA randomized clinical trial. Jama. 2019;321:1261.CrossRefGoogle Scholar