Evaluation of right ventricular pacing parameters in patients with proliferative scar

  • Veysel Kutay VurgunEmail author
  • Emir Baskovski
  • Huseyin Goksuluk
  • Nil Ozyuncu
  • Turkan Seda Tan
  • Ali Timucin Altin
  • Basar Candemir
  • Omer Akyurek



Dermal and myocardial injury results in a healing process, characterized by inflammation and fibrosis. We aimed to investigate association between proliferative scarring at the operation site and right ventricular (RV) pacing and sensing parameters, two clinical outcomes associated with impaired dermal and myocardial healing, respectively.


We performed an observational retrospective study among regularly followed pacemaker (PM)/implantable cardioverter defibrillator (ICD)-implanted patients at our medical center. Patients, who had a first RV active fixation PM/ICD lead implantation procedure and a minimum follow-up of 1 year, were included in the study. Redo procedures, passive fixation RV leads, epicardial leads, generator replacement procedures, and patients using class I and III anti-arrhythmic drugs were excluded. Patients in the control group, matched by age, sex and implanted device and lead type, were randomly selected from the patient pool. Lead impedance, pacing threshold, and R wave measurements obtained at baseline and at 3rd, 6th, and 12th month were analyzed.


Baseline characteristics of study and control groups were similar. While baseline and follow-up lead impedance and R wave measurements along with baseline and 3rd-month pacing thresholds showed no significant difference between two groups, 6th- and 12th-month pacing thresholds revealed statistically significant increase in proliferative scar group compared to control group (0.87 vs 0.72 p = 0.003 and 0.87 vs 0.71 p = 0.003, respectively).


PM/ICD-implanted patients with proliferative scar on pocket wound may show increased RV pacing thresholds compared to patients with normal healing of pocket wound.


Active fixation lead Implantable cardioverter defibrillator Proliferative scar Pacemaker Pacing threshold 



The authors would like to thank Senay Simsek for her assistance to the follow-up of the patients.

Author contributions

V.K.V. and H.G. designed this study. V.K.V., E.B., H.G., N.O., and T.S.T.K. collected and analyzed the data. O.A., A.T.A., and B.C. interpreted results of the study. V.K.V., E.B., and H.G. did statistical analyses, prepared figures, and wrote the paper. All authors edited and revised manuscript and approved final submission of manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethical Committee on Human Research in Ankara University School of Medicine (App No: 05-231-17).


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Cardiology DepartmentAnkara University School of MedicineMamakTurkey

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