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What is the true place of a double stimulation and double oocyte retrieval in the same cycle for patients diagnosed with poor ovarian reserve? A systematic review including a meta-analytical approach

  • Konstantinos Sfakianoudis
  • Konstantinos Pantos
  • Sokratis Grigoriadis
  • Anna Rapani
  • Evangelos Maziotis
  • Petroula Tsioulou
  • Polina Giannelou
  • Adamantia Kontogeorgi
  • Agni Pantou
  • Nikolaos Vlahos
  • Michael Koutsilieris
  • Mara SimopoulouEmail author
Assisted Reproduction Technologies
  • 36 Downloads

Abstract

Purpose

This systematic review including a meta-analytical approach aims to investigate the safety and efficacy of employing a double ovarian stimulation (DuoStim) and a subsequent double oocyte retrieval in the same menstrual cycle, in poor ovarian reserve (POR) patients.

Methods

A systematic search of literature was performed in the databases of PubMed/MEDLINE, Embase, and Cochrane Central Library up until March 2019. Both prospective and retrospective cohort studies considered suitable for inclusion reported on women with POR undergoing a DuoStim in the follicular (FPS) and luteal phase (LPS) of the same menstrual cycle. Following the systematic review of the literature, a meta-analytical approach was attempted.

Results

This study indicates that DuoStim is correlated with a higher number of retrieved oocytes, mature MII oocytes, and good-quality embryos in comparison to conventional stimulation. Additionally, LPS seems to be correlated with an equal or an even higher overall performance in comparison to FPS.

Conclusion

DuoStim favors an enhanced clinical outcome in regard to the total number of yielded oocytes, mature oocytes, and available embryos, along with the quality of obtained embryos. Sourced data indicate that LPS is not correlated with a higher aneuploidy rate. This option may present as promising for the time-sensitive nature of POR patients’ management, by enabling a higher oocyte yield during a single menstrual cycle.

Keywords

Luteal phase stimulation Follicular phase stimulation Double stimulation DuoStim Poor ovarian response 

Notes

Acknowledgments

The authors are very appreciative to all clinicians, embryologists, and scientists at the Centre for Human Reproduction at Genesis Hospital and at the Department of Physiology of the National and Kapodistrian University of Athens Medical School.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Konstantinos Sfakianoudis
    • 1
  • Konstantinos Pantos
    • 1
  • Sokratis Grigoriadis
    • 2
    • 3
  • Anna Rapani
    • 2
    • 3
  • Evangelos Maziotis
    • 2
    • 3
  • Petroula Tsioulou
    • 2
    • 3
  • Polina Giannelou
    • 1
    • 2
  • Adamantia Kontogeorgi
    • 2
  • Agni Pantou
    • 1
  • Nikolaos Vlahos
    • 3
  • Michael Koutsilieris
    • 2
  • Mara Simopoulou
    • 2
    • 3
    Email author
  1. 1.Centre for Human ReproductionGenesis Athens ClinicAthensGreece
  2. 2.Department of Physiology, Medical SchoolNational and Kapodistrian University of AthensAthensGreece
  3. 3.Assisted Conception Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical SchoolNational and Kapodistrian University of AthensAthensGreece

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