Live euploid birth and complete hydatid mole, followed by partial hydatid mole after ICSI
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Hydatidiform mole, also known as molar pregnancy, occurs in approximately one in every 600–800 pregnancies [1, 2, 3] and is the result of a genetic abnormality that causes growth of atypical in uterohyperplastic trophoblasts and hydropic villi. After one, or two consecutive, complete hydatidiform moles (CMs), the risks of a subsequent CM are 1 in 100 or 1 in 4, respectively; a partial hydatidiform mole (PM) only slightly increases the risk of a subsequent molar pregnancy . Molar pregnancies carry the risk of the development of gestational trophoblastic neoplasia (GTN), with approximately 10% of patients with CM and 1% of patients with PM requiring chemotherapy for GTN . van der Ven et al. reported an 8–10% incidence of PM following assisted reproductive procedures , including intracytoplasmic sperm injection (ICSI). Here, we describe a rare case of a patient who experienced a live euploid birth and spontaneous CM, followed by PM after ICSI.
- 18.Worrilow KC, Eid S, Woodhouse D, Perloe M, Smith S, Witmyer J, et al. Use of hyaluronan in the selection of sperm for intracytoplasmic sperm injection (ICSI): significant improvement in clinical outcomes—multicenter, double-blinded and randomized controlled trial. Hum Reprod. 2013;28(2):306–14.CrossRefPubMedGoogle Scholar
- 25.Vargas R, Barroilhet LM, Esselen K, Diver E, Bernstein M, Goldstein DP, et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med. 2014;59(5–6):188–94.PubMedGoogle Scholar