Journal of Assisted Reproduction and Genetics

, Volume 35, Issue 8, pp 1533–1536 | Cite as

Live euploid birth and complete hydatid mole, followed by partial hydatid mole after ICSI

  • Ming-Tzeung Chung
  • Chii-Ruey Tzeng
  • Ching-Hui Chen
  • Cindy Chan
  • Yi-En Chang
  • Yi-Hua Wu
  • Chi-Huang ChenEmail author
Assisted Reproduction Technologies


Hydatidiform mole, also known as molar pregnancy, occurs in approximately one in every 600–800 pregnancies [1, 2, 3] and is the result of a genetic abnormality that causes growth of atypical in uterohyperplastic trophoblasts and hydropic villi. After one, or two consecutive, complete hydatidiform moles (CMs), the risks of a subsequent CM are 1 in 100 or 1 in 4, respectively; a partial hydatidiform mole (PM) only slightly increases the risk of a subsequent molar pregnancy [4]. Molar pregnancies carry the risk of the development of gestational trophoblastic neoplasia (GTN), with approximately 10% of patients with CM and 1% of patients with PM requiring chemotherapy for GTN [2]. van der Ven et al. reported an 8–10% incidence of PM following assisted reproductive procedures [5], including intracytoplasmic sperm injection (ICSI). Here, we describe a rare case of a patient who experienced a live euploid birth and spontaneous CM, followed by PM after ICSI.

Case report



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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ming-Tzeung Chung
    • 1
    • 2
    • 3
  • Chii-Ruey Tzeng
    • 2
    • 3
  • Ching-Hui Chen
    • 2
    • 3
  • Cindy Chan
    • 2
    • 3
  • Yi-En Chang
    • 2
    • 3
  • Yi-Hua Wu
    • 2
    • 3
  • Chi-Huang Chen
    • 2
    • 3
    Email author
  1. 1.Department of Gynecology and ObstetricsTaipei City Hospital Ren-Ai BranchTaipeiTaiwan
  2. 2.Department of Obstetrics and GynecologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
  3. 3.Department of Obstetrics and GynecologyTaipei Medical University HospitalTaipeiTaiwan

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