The effect of day 2 versus day 3 embryo transfer on early pregnancy outcomes in women with a low yield of fertilized oocytes

  • C. R. Sacha
  • I. Dimitriadis
  • G. Christou
  • I. Souter
  • C. L. Bormann
Assisted Reproduction Technologies
  • 69 Downloads

Abstract

Purpose

To evaluate the differences in implantation and pregnancy rates when embryo transfer occurs on D2 versus D3 in women with a low yield of fertilized oocytes.

Methods

A total of 156 IVF/ICSI cycles from 141 women at an academic fertility center were analyzed in a retrospective fashion. Women with a low number of fertilized oocytes (≤ 2 two pronuclei (2PN) stage zygotes) who had their fresh embryo transfer on D2 or D3 were included in the study. Positive pregnancy test per IVF cycle (PPT), clinical pregnancy rate (CPR), spontaneous abortion rate (SABR), and implantation rate (IMPR) were the main outcome measures assessed. Mann-Whitney U test and χ2 test were used as appropriate. A generalized linear mixed effect model adjusted for relevant covariates was conducted. P < 0.05 was considered significant.

Results

Patients having their embryo transfer on D2, when compared to those who had a D3 embryo transfer, experienced similar PPT [30.8 vs. 28.2%, respectively; adjusted OR (95%CI): 0.49 (0.16, 1.52)], CPR [26.9 vs. 25.6%, respectively; adjusted OR (95%CI): 0.44 (0.12, 1.67)], and IMPR [17.3 vs. 16.7%, respectively; adjusted β (95%CI) − 5.6% (− 15.0, 3.9)].

Conclusion

Our findings suggest that transferring embryos on D2 versus D3 in women with a limited number of 2PN stage zygotes does not affect early pregnancy outcomes. These results indicate that there can be some flexibility in scheduling the day of transfer at the convenience of both the patient and the center.

Keywords

IVF Embryo transfer 2PN Implantation rate Pregnancy outcomes 

Notes

Acknowledgements

The authors acknowledge the embryology laboratory staff at Massachusetts General Hospital for their role in preparing embryos for transfer, as well as Kaitlyn James for her assistance with the statistical analyses.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • C. R. Sacha
    • 1
  • I. Dimitriadis
    • 1
    • 2
  • G. Christou
    • 2
    • 3
  • I. Souter
    • 1
    • 2
  • C. L. Bormann
    • 1
    • 2
  1. 1.Department of Obstetrics, Gynecology, and Reproductive Endocrinology and InfertilityMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Massachusetts General Hospital Fertility CenterBostonUSA
  3. 3.Department of Environmental HealthHarvard T. H. Chan School of Public HealthBostonUSA

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