A Pilot Randomized Clinical Trial of a Multidisciplinary Intervention for Encopresis in Children with Autism Spectrum Disorder
Children with autism spectrum disorder (ASD) are often delayed in achieving bowel continence, resulting in negative outcomes. In this pilot trial, 20 children with ASD and encopresis were randomly assigned to multidisciplinary intervention for encopresis (MIE; n = 10) or a waitlist control group (n = 10). The MIE group was treated for constipation and received a 10-day behavioral intervention that utilized suppositories to produce predictable bowel movements that were reinforced. Caregivers were trained to implement the intervention. Results support the feasibility of clinical trials of MIE, with high enrolment, competition, attendance, and caregiver acceptability. Preliminary outcomes were positive, with six of 10 in the MIE group achieving continence by the end of treatment compared to 0 in the control group (p = 0.005).
Registered at clinicaltrials.gov (https://clinicaltrials.gov); ID: NCT02383732.
KeywordsEncopresis Multidisciplinary treatment Pediatric gastroenterology
All authors contributed to the study conception, design, data collection and/or study implementation. Material preparation, data collection and analysis were performed by JLM, NAC, KRG, MS, SJM, CM, SH, CM, LS, and BOM. JLM wrote the first draft of the manuscript and all authors contributed on previous versions of the manuscript. All authors read and approved the final manuscript with the expectation of SH who had left the organization prior to completion of the final manuscript.
Funding was provided by Organization for Autism Research.
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