Largely Typical Electrophysiological Affective Responses to Special Interest Stimuli in Adolescents with Autism Spectrum Disorder
Circumscribed interests are a symptom of autism spectrum disorder (ASD) that may be related to exaggerated affective neural responses. However, the use of generic ASD-interest image stimuli has left an open question as to whether affective responses towards individual interests are greater in ASD compared to typically developing (TD) controls. We compared amplitudes of the late positive potential (LPP), an affective electroencephalographic response, between adolescents with ASD (N = 19) and TD adolescents (N = 20), using images tailored to individual likes and dislikes. We found an LPP response for liked and disliked images, relative to neutral, with no difference in amplitude between groups. This suggests that the LPP is not atypical in adolescents with ASD towards images of individual interests.
KeywordsAutism spectrum disorder EEG LPP Affective Circumscribed interests
We would like to acknowledge the support of a SickKids Foundation and CIHR-IHDCYH New Investigator Award to SB (NI14-021), the Sinneave Family Foundation, the Alberta Chlidren’s Hospital Foundation, a Canadian Foundation for Innovation Leaders Opportunity Fund (30320, https://www.innovation.ca/) award to AP, an Alberta Enterprise and Advanced Education Research Capacity Program, Alberta Alignment Grant (RCP-13-38SEG; http://economic.alberta.ca/Research-Capacity-Program.asp). We would like to thank all of the families who took the time to participate in this study. Data included in this manuscript were collected as part of Keelin Rivard’s MSc thesis, and findings were previously presented at the Society for Neuroscience 2016 annual meeting.
The authors KR, DD, AWM, ABP and SB have designed the research. KR, FB, KE, IC, FC and MS have performed research. KR, ABP and SB have wrote the first draft of the manuscript. All authors contributed to revising the manuscript.
This work was supported by a SickKids Foundation and CIHR-IHDCYH award to SB (NI14-021), the Sinneave Family Foundation (SB), the Alberta Children’s Hospital Foundation (SB), the Canadian Foundation for Innovation Leaders Opportunity Fund (30320;ABP), and the Alberta Enterprise and Advanced Education Research Capacity Program, Alberta Alignment Grant (RCP-13-38-SEG,ABP).
Compliance with Ethical Standards
Conflict of interest
All authors declare that they have no conflicts of interest.
- Benning, S. D., Kovac, M., Campbell, A., Miller, S., Hanna, E. K., Damiano, C. R., et al. (2016). Late positive potential ERP responses to social and nonsocial stimuli in youth with autism spectrum disorder. Journal of Autism and Developmental Disorders, 46(9), 3068–3077.PubMedPubMedCentralCrossRefGoogle Scholar
- Constantino, J. N., & Gruber, C. P. (2002). The social responsiveness scale. Los Angeles: Western Psychological.Google Scholar
- Evans, D. W., Kleinpeter, F. L., Slane, M. M., & Boomer, K. B. (2014). Adaptive and maladaptive correlates of repetitive behavior and restricted interests in persons with down syndrome and developmentally-matched typical children: A two-year longitudinal sequential design. PLoS ONE, 9(4), e93951.PubMedPubMedCentralCrossRefGoogle Scholar
- Foss-Feig, J. H., McGugin, R. W., Gauthier, I., Mash, L. E., Ventola, P., & Cascio, C. J. (2016). A functional neuroimaging study of fusiform response to restricted interests in children and adolescents with autism spectrum disorder. Journal of Neurodevelopmental Disorders, 8, 15.PubMedPubMedCentralCrossRefGoogle Scholar
- Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2(3), 217–250.Google Scholar
- Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (2008). International affective picture system (IAPS): Affective ratings of pictures and instruction manual. Technical report A-8.Google Scholar
- Lord, C., Rutter, M., DiLavore, P., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule, 2nd edition (ADOS-2). Torrance: Western Psychological Services.Google Scholar
- Wechsler, D. (2012). Wechsler abbreviated scale of intelligence—Second edition manual. Bloomington, MN: Pearson.Google Scholar