Cost-Effectiveness of Universal or High-Risk Screening Compared to Surveillance Monitoring in Autism Spectrum Disorder
The American Academy of Pediatrics recommends universal screening for autism spectrum disorder at 18 and 24 months. This study compared the cost-effectiveness of universal or high-risk screening to surveillance monitoring. Simulation models estimated the costs and outcomes from birth to age 6 years. The incremental cost per child diagnosed by 36 months was $41,651.6 for high-risk screening and $757,116.9 for universal screening from the societal perspective. Universal screening may not be a cost-effective approach to increase earlier treatment initiation, as most children initiated treatment after age 60 months. Eliminating wait times resulted in more children initiated treatment by 48 months, but at a high initial cost that may be offset by future cost-savings related to better outcomes.
KeywordsAutism spectrum disorder Cost-effectiveness analysis Health services research Screening
Tracy Yuen was supported through the Canada Institutes of Health Research Autism Research Training Program, Doctoral Autism Scholars Award, Ontario Graduate Scholarship and RestraComp Hospital for Sick Children Foundation Student Scholarship Program. The funders had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The work is based on the doctoral dissertation of Dr. T. Yuen. The authors wish to thank Drs. Jessica Brian, Susan Bryson, Isabel Smith and Lonnie Zwaigenbaum for sharing data from the “Canadian high risk infant cohort” (Infant Sibling study) which informed the observed ASD status for all children and trajectories for high-risk children.
All authors (TY, MTC, PS, WJU) contributed to the conceptualization of the model, interpretation of findings, editing of the manuscript andn provided final approval of the paper. TY and WJU were responsible for model building, data analysis and drafting of the manuscript.
Compliance with Ethical Standards
Conflict of interest
All authors declare no conflicts of interest.
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