Brief Report: Autism Spectrum Disorder: A Comprehensive Survey of Randomized Controlled Trials
- 682 Downloads
We searched the Cochrane Central Register of Controlled Trials to provide an overview of evidence from randomized controlled trials (RCTs) of therapeutic interventions for autism spectrum disorders. From the final survey (529 RCTs), the mean size was 49 participants (standard deviation 50, range 1–479, median 36, mode 40), with a sharp increase in the number of RCTs from 2008. The most frequently evaluated intervention was antipsychotic treatment (n = 44, 3006 participants). The journal with the most RCTs was the Journal of Autism and Developmental Disorders (N = 104). Most trials were small in size, emphasising the need for research groups to collaborate to generate higher quality data with greater applicability to clinical practice.
KeywordsAutism Autistic ASD Randomized Trials Survey
The authors would like to thank the Cochrane Schizophrenia Group for the provision of data and library services.
ST conceived of the study, participated in its design, led in its coordination and drafted the manuscript; CA conceived of the study, led in its design, participated in its coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
Compliance with Ethical Standards
Conflict of interest
Samuel Tromans and Clive Adams declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- CENTRAL creation details (2014). Retrieved June 26, 2017 from http://www.cochranelibrary.com/help/central-creation-details.html.
- Dove, D., Warren, Z., McPheeters, M. L., Taylor, J. L., Sathe, N. A., & Veenstra-VanderWeele, J. (2012). Medications for adolescents and young adults with autism spectrum disorders: A systematic review. Pediatrics, 130(4), 717–726. https://doi.org/10.1542/peds.2012-0683.CrossRefPubMedPubMedCentralGoogle Scholar
- Huang, X., Lin, J., & Demner-Fushman, D. (2006). Evaluation of PICO as a knowledge representation for clinical questions. In AMIA annual symposium proceedings, pp. 359–363.Google Scholar
- Interagency Autism Coordinating Committee. (2017). 2016–2017 interagency autism coordinating committee strategic plan for autism spectrum disorder. Retrieved February 8, 2017 from https://iacc.hhs.gov/publications/strategic-plan/2017/.
- Postorino, V., Sharp, W. G., McCracken, C. E., Bearss, K., Burrell, T. L., Evans, A. N., et al. (2017). A systematic review and meta-analysis of parent training for disruptive behavior in children with autism spectrum disorder. Clinical Child and Family Psychology Review, 20(4), 391–402.CrossRefPubMedGoogle Scholar
- U.S National Library of Medicine. (2018). ClinicalTrials.gov. Retrieved February 8, 2018 from https://clinicaltrials.gov/ct2/results?cond=Autism&term=&cntry=&stage=&city=&dist=.
- Wessely, S. (2007). Randomised, controlled trials. In Choosing methods in mental health research: Mental health research from theory to practice (pp. 85–98). New York: Psychology Press.Google Scholar