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Journal of Autism and Developmental Disorders

, Volume 48, Issue 8, pp 2800–2808 | Cite as

The Clinical Features of Comorbid Pediatric Bipolar Disorder in Children with Autism Spectrum Disorder

  • Dicle Sapmaz
  • Saliha Baykal
  • Seher Akbaş
Original Paper

Abstract

The aim of this study was to describe clinical features of PBD comorbidity in children with ASD. Forty children with ASD and PBD aged 6–18 years, and 40 age- and sex-matched ASD subjects with no affective episodes were included in the study. Autism Behavior CheckList, Abberant Behavior CheckList, and Young Mania Rating Scale-Parent Version were completed. This study shows that PBD comorbidity in children with ASD involves a highly episodic course, with manic episodes, subsyndromal symptoms and interepisodic periods commonly being described in the manic symptom profile of these children. These findings need to be repeated with large samples, together with controlled studies concerning therapeutic interventions directed toward PBD comorbidity in children with ASD.

Keywords

Autism Spectrum Disorders Pediatric Bipolar Disorders Comorbidity 

Notes

Author Contributions

DS, SB, SA are involved in determining the aim and method of the research, and in the data collection, data analysis, reviewing the existing literature, and writing stages.

References

  1. Aman, G. M., Singh, N. N., Stewart, A. W., et al. (1985). The Aberrant Behavior Checklist. American Journal of Mental Deficiency, 89(5), 485–491.PubMedGoogle Scholar
  2. American Psychiatric Association (2013) Diagnostic and statictical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association.CrossRefGoogle Scholar
  3. Boso, M., Comelli, M., Emanuele, E., et al. (2010). Seasonal fluctuations in problem behaviors among young adults with autism and intellectual disability. Medical Science Monitor, 16(5), 213–216.Google Scholar
  4. De Bruin, E., Ferdinand, R., Meester, S., et al. (2007). High rates of psychiatric comorbidity in PDD-NOS. Journal of Autism and Developmental Disorders, 37(5), 877–886.CrossRefPubMedGoogle Scholar
  5. Dejong, S., & Frazier, J. A. (2003). Bipolar disorder in children with pervasive developmental disorders. In M. P. DelBello & B. Geller, Bipolar disorder in childhood and early adolescence. New York: The Guilford Press.Google Scholar
  6. Diler, R. S., Uğuz, S., Seydaoğlu, G., et al. (2007). Differentiating bipolar disorder in Turkish prepubertal children with attention-deficit hyperactivity disorder. Bipolar Disorders, 9, 243–251.CrossRefPubMedGoogle Scholar
  7. Faeda, G. L., Baldesarrini, R. J., Glovinski, I. P., et al. (2004). Pediatric bipolar disorder; phenomenology and course of illnes. Bipolar Disorders, 6(4), 305–313.CrossRefGoogle Scholar
  8. Findling, R. L., Gracious, B. L., & McNamara, N. K. (2001). Rapid, continuous cycling and psychiatric comorbidity in pediatric bipolar I disorder. Bipolar Disorders, 3(4), 202–210.CrossRefPubMedGoogle Scholar
  9. Frazier, J. A., Doyle, R., Chiu, S., & Coyle, J. T. (2002). Treating a child with Asperger’s disorder and comorbid Bipolar Disorder. American Journal of Psychiatry, 159(1), 13–21.CrossRefPubMedGoogle Scholar
  10. Ghaziuddin, M., Weidmer-Mikhail, E., & Ghaziuddin, N. (1998). Comorbidity of Asperger sydrome; a preliminary report. Journal of Intellectual Disability Research, 42(4), 279–283.CrossRefPubMedGoogle Scholar
  11. Gökler, B., Ünal, F., Pehlivantürk, B., et al. (2004). Okul Çağı Çocukları için Duygulanım Bozuklukları ve Şizofreni Görüşme Çizelgesi-Şimdi ve Yaşamboyu Şekli-Türkçe Uyarlamasının Geçerliliği ve Güvenilirliği. Çocuk ve Gençlik Ruh Sağlığı Dergisi, 11(3), 109–116.Google Scholar
  12. Gracious, B. L., Youngstrom, E. A., Findling, R. L., et al. (2002). Discriminative validity of a parent version of the Young Mania Rating Scale. Journal of the American Academy Child Adolescence Psychiatry, 41(11), 1350–1359.CrossRefGoogle Scholar
  13. Hayashi, E. (2001). Seasonal changes in sleep and behavioral problems in a pubescent case with autism. Psychiatry and Clinical Neurosciences, 55(3), 223–224.CrossRefPubMedGoogle Scholar
  14. Hofvander, B., Delorme, R., Chaste, P., et al. (2009). Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders. BMC Psychiatry, 9, 35.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Howell, C., Larson, J., & Coffey, B. J. (2011). Treatment of bipolar disorder in an adolescent with autistic disorder: A diagnostic and treatment dilemma. Journal of Child and Adolescent Psychopharmacology, 21(3), 283–286.CrossRefPubMedGoogle Scholar
  16. Hutton, J., Goode, S., Murphy, M., et al. (2008). New-onset psychiatric disorders in individuals with autism. Autism, 12(4), 373–390.CrossRefPubMedGoogle Scholar
  17. Joshi, G., Biederman, J., Petty, C., et al. (2013). Examining the comorbidity of bipolar disorder and autism spectrum disorders: A large controlled analysis of phenotypic and familial correlates in a referred population of youth with bipolar i disorder with and without autism spectrum disorders. Journal of Clinical Psychiatry, 74(6), 578–586.CrossRefPubMedGoogle Scholar
  18. Kaat, A. J., Lecavalier, L., & Aman, M. G. (2014). Validity of the Aberrant Behavior Checklist in children with autism spectrum disorder. Journal of Autism and Developmental, Disorders44(5), 1103–1116.CrossRefGoogle Scholar
  19. Kaufman, J., Birmaher, B., & Brent, D. (1997). Schedule for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy Child Adolescence Psychiatry, 36(7), 980–988.CrossRefGoogle Scholar
  20. King, R., Fay, G., & Croghan, P. (2000). Rapid cycling bipolar disorder in individuals with developmental disabilities. Mental Retardation, 38(3), 253–261.CrossRefPubMedGoogle Scholar
  21. Krug, D. A., Arick, J., & Almond, P. (1980). Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior. Journal of Child Psychology and Psychiatry, 21(3), 221–229.CrossRefPubMedGoogle Scholar
  22. Kurita, H., & Nakayasu, N. (1994). Brief report: An autistic male presenting seasonal affective disorder and trichotillomania. Journal of Autism and Developmental Disorders, 24(5), 687–692.CrossRefPubMedGoogle Scholar
  23. Kurita, H., Osada, H., Shimizu, K., et al. (2004). Bipolar disorders in mentally retarded persons with pervasive developmental disorders. Journal of Developmental and Physical Disabilities, 16(4), 377–389.CrossRefGoogle Scholar
  24. Lainhart, J. E., & Folstein, S. E. (1994). Affective disorders in people with autism: A review of published cases. Journal of Autism and Developmental Disorders, 24(5), 587–601.CrossRefPubMedGoogle Scholar
  25. Leyfer, O., Folstein, S., Bacalman, S., et al. (2006). Comorbid psychiaytric disorders in children with autism: Interview development and rates of disorders. Journal of Autism and Developmental Disorders, 36(7), 849–861.CrossRefPubMedGoogle Scholar
  26. LoVullo, S. V., & Matson, J. L. (2009). Comorbid psychopathology in adults with autism spectrum disorders and intellectual disabilities. Research in Developmental Disabilities, 30(6), 1288–1296.CrossRefPubMedGoogle Scholar
  27. Lugnegard, T., Hallerback, M. U., & Gillberg, C. (2011). Psychiatric comorbidity in young adults with clinical diagnosis of Asperger syndrome. Research in Developmental Disabilities, 32(5), 1910–1917.CrossRefPubMedGoogle Scholar
  28. Mazefksky, C., Oswald, D., Day, T., et al. (2012). ASD, a psychiatric disorder, or both? psychiatric diagnoses in adolescents with high functioning ASD. Journal of Clinical Child and Adolescent Psychology, 41(4), 516–523.CrossRefGoogle Scholar
  29. Mukaddes, N. M. (2013). Otizm Spektrum Bozuklukları: Tanı ve Takip. İstanbul: Nobel Tıp Kitabevleri.Google Scholar
  30. Mukaddes, N. M., & Fateh, R. (2010). High Rates of Psychiatric comorbidity in individuals with Asperger’s disorder. The World Journal of Biological Psychiatry, 11(2), 486–492.CrossRefPubMedGoogle Scholar
  31. Munesue, T., Ono, Y., Mutoh, K., et al. (2008). High prevalance of bipolar disorder comorbidity in adolescents and young adults with high-functioning autism spectrum disorder: A preliminary study of 44 outpatients. Journal of Affective Disorders, 111(2–3), 170–175.CrossRefPubMedGoogle Scholar
  32. Pavuluri, M. N., Hendry, D. B., & Carbray, J. A. (2005). Divalproex sodium for pediatric mixed mania: A 6 month prospective trial. Bipolar Disorders, 7(3), 266–273.CrossRefPubMedGoogle Scholar
  33. Sucuoğlu, B. (2003). Sorun Davranışları Kontrol Listesi Türkçe Formunun Psikometrik Özelliklerinin İncelenmesi. Türk Psikoloji Dergisi, 18(52), 77–91.Google Scholar
  34. Vanucchi, G. (2014). Bipolar disorder in adults with Asperger’s syndrome: A systematic review. Journal of Affective Disorders, 168, 151–160.CrossRefGoogle Scholar
  35. Wozniak, J., Biederman, J., Faraone, S. V., et al. (1997). Mania in children with pervasive developmental disorder revisited. Journal of the American Academy Child Adolescence Psychiatry, 36(11), 1552–1559.Google Scholar
  36. Wozniak, J., Biederman, J., & Kiely, K. (1995). Mania like symptom suggestive of childhood-onset bipolar disorder in clinically referred sample. Journal of the American Academy of Child and Adolescence Psychiatry, 34(7), 867–876.CrossRefGoogle Scholar
  37. Yılmaz, I. T., Tekinsav, S. S., Aydın, A., et al. (2007). Otizm Davranış Kontrol Listesinin (ABC) geçerlilik ve güvenilirliğinin incelenmesi. Çocuk ve Gençlik Ruh Sağlığı Dergisi, 14(1), 13–23.Google Scholar
  38. Youngstrom, E. A., Gracious, B. L., Danielson, C. K., et al. (2003). Toward an integration of parent and clinician report on the Young Mania Rating Scale. Journal Of Affective Disorders, 77, 179–190.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Child and Adolescent PsychiatryÇanakkale State HospitalÇanakkaleTurkey
  2. 2.Department of Child and Adolescent Psychiatry, Faculty of MedicineUniversity of Namık KemalTekirdağTurkey
  3. 3.Department of Child and Adolescent Psychiatryİstinye UniversityIstanbulTurkey

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