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Journal of Abnormal Child Psychology

, Volume 47, Issue 5, pp 881–894 | Cite as

Age Moderates Link Between Training Effects and Treatment Response to Attention Bias Modification Treatment for Social Anxiety Disorder

  • Rany AbendEmail author
  • Reut Naim
  • Lee Pergamin-Hight
  • Nathan A. Fox
  • Daniel S. Pine
  • Yair Bar-Haim
Article

Abstract

Attention bias modification treatment (ABMT) aims to reduce anxiety symptoms via practice on computerized attention training tasks. Despite evidence of efficacy, clinical effects appear heterogeneous. More research on ABMT mechanisms and moderators of treatment response is needed. Age is one potentially important moderator, as developmental differences in training effects may impact response. We examined developmental links between ABMT training effects and response in social anxiety disorder (SAD). We pooled data from two randomized controlled trials in treatment-seeking youths and adults with SAD (N = 99) that used identical ABMT methods. We first characterized learning effects associated with the eight-session ABMT training protocol. We then tested whether learning magnitude predicted the clinical (change in SAD symptoms) and cognitive (change in attention bias) responses to treatment. Finally, we tested whether age moderated the association between ABMT learning and treatment response. Results indicate that ABMT was associated with an incremental learning curve during the protocol, and that learning improved with age. Age further moderated the association between learning gains during the ABMT protocol and subsequent reduction in self-reported SAD symptoms, such that this association was stronger with age. These effects were not evident in bias scores or clinician ratings. Finally, pre-treatment SAD symptoms and bias scores predicted ABMT learning gains. This study highlights the links among age, learning processes, and clinical response to ABMT. These insights may inform attempts to increase the clinical efficacy of ABMT for anxiety.

Keywords

Anxiety Development Attention bias Treatment Learning Children Age 

Notes

Acknowledgements

This research was supported in part by the Intramural Research Program of the National Institute of Mental Health (ZIAMH002781-15, NCT00018057).

Compliance with Ethical Standards

Conflict of Interest

All authors declare no conflicts of interests.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

10802_2018_494_MOESM1_ESM.docx (64 kb)
ESM 1 (DOCX 64 kb)

References

  1. Abe, M., Schambra, H., Wassermann, E. M., Luckenbaugh, D., Schweighofer, N., & Cohen, L. G. (2011). Reward improves long-term retention of a motor memory through induction of offline memory gains. Current Biology, 21(7), 557–562.  https://doi.org/10.1016/j.cub.2011.02.030.Google Scholar
  2. Abend, R., Karni, A., Sadeh, A., Fox, N. A., Pine, D. S., & Bar-Haim, Y. (2013). Learning to attend to threat accelerates and enhances memory consolidation. PLoS One, 8(4), e62501.  https://doi.org/10.1371/journal.pone.0062501.Google Scholar
  3. Abend, R., Pine, D. S., & Bar-Haim, Y. (2014a). The TAU-NIMH attention bias measurement toolbox. Retrieved from http://people.socsci.tau.ac.il/mu/anxietytrauma/research/.
  4. Abend, R., Pine, D. S., Fox, N. A., & Bar-Haim, Y. (2014b). Learning and memory consolidation processes of attention-bias modification in anxious and nonanxious individuals. Clinical Psychological Science, 2(5), 620–627.Google Scholar
  5. Abend, R., de Voogd, E. L., Salemink, E., Wiers, R. W., Perez-Edgar, K., Fitzgerald, A., ... Bar-Haim, Y. (2018). Association between attention bias to threat and anxiety symptoms in children and adolescents. Depression and Anxiety, 35(3), 229–238.  https://doi.org/10.1002/da.22706.
  6. Acarturk, C., Cuijpers, P., van Straten, A., & de Graaf, R. (2009). Psychological treatment of social anxiety disorder: a meta-analysis. Psychological Medicine, 39(2), 241–254.  https://doi.org/10.1017/S0033291708003590.Google Scholar
  7. Albano, A. M., & Silverman, W. K. (1996). The anxiety disorders interview schedule for children for DSM-IV: clinician manual (child and parent versions). San Antonio: Psychological Corporation.Google Scholar
  8. Amso, D., & Scerif, G. (2015). The attentive brain: insights from developmental cognitive neuroscience. Nature Reviews Neuroscience, 16(10), 606–619.  https://doi.org/10.1038/nrn4025.Google Scholar
  9. Antony, M. M., Coons, M. J., McCabe, R. E., Ashbaugh, A., & Swinson, R. P. (2006). Psychometric properties of the social phobia inventory: further evaluation. Behaviour Research and Therapy, 44(8), 1177–1185.  https://doi.org/10.1016/j.brat.2005.08.013.Google Scholar
  10. Arad, G., & Bar-Haim, Y. (2017). Commentary: information-processing in anxiety and depression: novel targets for translational research – a reflection on Lau and waters (2017). Journal of Child Psychology and Psychiatry, 58(4), 408–410.  https://doi.org/10.1111/jcpp.12717.Google Scholar
  11. Bandelow, B., Reitt, M., Rover, C., Michaelis, S., Gorlich, Y., & Wedekind, D. (2015). Efficacy of treatments for anxiety disorders: a meta-analysis. International Clinical Psychopharmacology, 30(4), 183–192.  https://doi.org/10.1097/YIC.0000000000000078.Google Scholar
  12. Bantin, T., Stevens, S., Gerlach, A. L., & Hermann, C. (2016). What does the facial dot-probe task tell us about attentional processes in social anxiety? A systematic review. Journal of Behavior Therapy and Experimental Psychiatry, 50, 40–51.  https://doi.org/10.1016/j.jbtep.2015.04.009.Google Scholar
  13. Bar-Haim, Y. (2010). Research review: attention bias modification (ABM): a novel treatment for anxiety disorders. Journal of Child Psychology and Psychiatry, 51(8), 859–870.  https://doi.org/10.1111/j.1469-7610.2010.02251.x.Google Scholar
  14. Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychological Bulletin, 133(1), 1–24.  https://doi.org/10.1037/0033-2909.133.1.1.Google Scholar
  15. Beard, C., Weisberg, R. B., & Primack, J. (2012). Socially anxious primary care patients’ attitudes toward cognitive bias modification (CBM): a qualitative study. Behavioural and Cognitive Psychotherapy, 40(5), 618–633.  https://doi.org/10.1017/S1352465811000671.Google Scholar
  16. Beesdo, K., Knappe, S., & Pine, D. S. (2009). Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psychiatric Clinics of North America, 32(3), 483–524.  https://doi.org/10.1016/j.psc.2009.06.002.Google Scholar
  17. Beidel, D. C., Turner, S. M., & Morris, T. L. (1995). A new inventory to assess childhood social anxiety and phobia - the social phobia and anxiety inventory for children. Psychological Assessment, 7(1), 73–79.  https://doi.org/10.1037/1040-3590.7.1.73.Google Scholar
  18. Beidel, D. C., Turner, S. M., & Fink, C. M. (1996). Assessment of childhood social phobia: construct, convergent, and discriminative validity of the social phobia and anxiety inventory for children (SPAI-C). Psychological Assessment, 8(3), 235–240.  https://doi.org/10.1037/1040-3590.8.3.235.Google Scholar
  19. Blakemore, S. J. (2008). The social brain in adolescence. Nature Reviews Neuroscience, 9(4), 267–277.  https://doi.org/10.1038/nrn2353.Google Scholar
  20. Blanco, C., Schneier, F. R., Schmidt, A., Blanco-Jerez, C. R., Marshall, R. D., Sanchez-Lacay, A., & Liebowitz, M. R. (2003). Pharmacological treatment of social anxiety disorder: a meta-analysis. Depression and Anxiety, 18(1), 29–40.  https://doi.org/10.1002/da.10096.Google Scholar
  21. Boendermaker, W. J., Sanchez Maceiras, S., Boffo, M., & Wiers, R. W. (2016). Attentional bias modification with serious game elements: evaluating the shots game. JMIR Serious Games, 4(2), e20.  https://doi.org/10.2196/games.6464.Google Scholar
  22. Brodeur, D. A., & Boden, C. (2000). The effects of spatial uncertainty and cue predictability on visual orienting in children. Cognitive Development, 15(3), 367–382.  https://doi.org/10.1016/S0885-2014(00)00025-3.Google Scholar
  23. Browning, M., Holmes, E. A., Murphy, S. E., Goodwin, G. M., & Harmer, C. J. (2010). Lateral prefrontal cortex mediates the cognitive modification of attentional bias. Biological Psychiatry, 67(10), 919–925.  https://doi.org/10.1016/j.biopsych.2009.10.031.Google Scholar
  24. Burki, C. N., Ludwig, C., Chicherio, C., & de Ribaupierre, A. (2014). Individual differences in cognitive plasticity: an investigation of training curves in younger and older adults. Psychological Research, 78(6), 821–835.  https://doi.org/10.1007/s00426-014-0559-3.Google Scholar
  25. Casey, B. J., Tottenham, N., Liston, C., & Durston, S. (2005). Imaging the developing brain: what have we learned about cognitive development? Trends in Cognitive Sciences, 9(3), 104–110.  https://doi.org/10.1016/j.tics.2005.01.011.Google Scholar
  26. Cisler, J. M., Bacon, A. K., & Williams, N. L. (2009). Phenomenological characteristics of attentional biases towards threat: a critical review. Cognitive Therapy and Research, 33(2), 221–234.  https://doi.org/10.1007/s10608-007-9161-y.Google Scholar
  27. Clarke, P. J., Browning, M., Hammond, G., Notebaert, L., & MacLeod, C. (2014). The causal role of the dorsolateral prefrontal cortex in the modification of attentional bias: evidence from transcranial direct current stimulation. Biological Psychiatry, 76(12), 946–952.  https://doi.org/10.1016/j.biopsych.2014.03.003.Google Scholar
  28. Connolly, S. D., & Bernstein, G. A. (2007). Practice parameter for the assessment and treatment of children and adolescents with anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 46(2), 267–283.  https://doi.org/10.1097/01.chi.0000246070.23695.06.Google Scholar
  29. Connor, K. M., Davidson, J. R., Churchill, L. E., Sherwood, A., Foa, E., & Weisler, R. H. (2000). Psychometric properties of the social phobia inventory (SPIN). New self-rating scale. British Journal of Psychiatry, 176, 379–386.Google Scholar
  30. Corbetta, M., & Shulman, G. L. (2002). Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews Neuroscience, 3(3), 201–215.  https://doi.org/10.1038/nrn755.Google Scholar
  31. Cristea, I. A., Kok, R. N., & Cuijpers, P. (2015). Efficacy of cognitive bias modification interventions in anxiety and depression: meta-analysis. British Journal of Psychiatry, 206(1), 7–16.  https://doi.org/10.1192/bjp.bp.114.146761.Google Scholar
  32. Cuthbert, B. N., & Insel, T. R. (2013). Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Medicine, 11, 126.  https://doi.org/10.1186/1741-7015-11-126.Google Scholar
  33. De Voogd, E. L., Wiers, R. W., Prins, P. J., & Salemink, E. (2014). Visual search attentional bias modification reduced social phobia in adolescents. Journal of Behavior Therapy and Experimental Psychiatry, 45(2), 252–259.  https://doi.org/10.1016/j.jbtep.2013.11.006.Google Scholar
  34. de Voogd, E. L., Wiers, R. W., Prins, P. J., de Jong, P. J., Boendermaker, W. J., Zwitser, R. J., & Salemink, E. (2016). Online attentional bias modification training targeting anxiety and depression in unselected adolescents: short- and long-term effects of a randomized controlled trial. Behaviour Research and Therapy, 87, 11–22.  https://doi.org/10.1016/j.brat.2016.08.018.Google Scholar
  35. De Voogd, E. L., Wiers, R. W., & Salemink, E. (2017). Online visual search attentional bias modification for adolescents with heightened anxiety and depressive symptoms: a randomized controlled trial. Behaviour Research and Therapy, 92, 57–67.  https://doi.org/10.1016/j.brat.2017.02.006.Google Scholar
  36. Dennis, T. A., & O’Toole, L. J. (2014). Mental health on the go: effects of a gamified attention-bias modification mobile application in trait-anxious adults. Clinical Psychological Science, 2, 576–590.  https://doi.org/10.1177/2167702614522228.Google Scholar
  37. DeWit, D. J., Ogborne, A., Offord, D. R., & MacDonald, K. (1999). Antecedents of the risk of recovery from DSM-III-R social phobia. Psychological Medicine, 29(3), 569–582.Google Scholar
  38. Dovis, S., Van der Oord, S., Wiers, R. W., & Prins, P. J. M. (2012). Can motivation normalize working memory and task persistence in children with attention-deficit/hyperactivity disorder? The effects of money and computer-gaming. Journal of Abnormal Child Psychology, 40(5), 669–681.  https://doi.org/10.1007/s10802-011-9601-8.Google Scholar
  39. Doyon, J., Korman, M., Morin, A., Dostie, V., Hadj Tahar, A., Benali, H., ... Carrier, J. (2009). Contribution of night and day sleep vs. simple passage of time to the consolidation of motor sequence and visuomotor adaptation learning. Experimental Brain Research, 195(1), 15–26.  https://doi.org/10.1007/s00221-009-1748-y.
  40. Eberl, C., Wiers, R. W., Pawelczack, S., Rinck, M., Becker, E. S., & Lindenmeyer, J. (2013). Implementation of approach bias re-training in alcoholism-how many sessions are needed? Alcoholism, Clinical and Experimental Research, 38, 587–594.  https://doi.org/10.1111/acer.12281.Google Scholar
  41. Eldar, S., Apter, A., Lotan, D., Edgar, K. P., Naim, R., Fox, N. A., ... Bar-Haim, Y. (2012). Attention bias modification treatment for pediatric anxiety disorders: A randomized controlled trial. American Journal of Psychiatry, 169(2), 213–220.Google Scholar
  42. Fischer, S., & Born, J. (2009). Anticipated reward enhances offline learning during sleep. Journal of Experimental Psychology: Learning, Memory, and Cognition, 35(6), 1586–1593.  https://doi.org/10.1037/a0017256.Google Scholar
  43. Fresco, D. M., Coles, M. E., Heimberg, R. G., Liebowitz, M. R., Hami, S., Stein, M. B., & Goetz, D. (2001). The Liebowitz social anxiety scale: a comparison of the psychometric properties of self-report and clinician-administered formats. Psychological Medicine, 31(6), 1025–1035.  https://doi.org/10.1017/S0033291701004056.
  44. Ginsburg, G. S., Becker, E. M., Keeton, C. P., Sakolsky, D., Piacentini, J., Albano, A. M., ... Kendall, P. C. (2014). Naturalistic follow-up of youths treated for pediatric anxiety disorders. JAMA Psychiatry, 71(3), 310–318.  https://doi.org/10.1001/jamapsychiatry.2013.4186.
  45. Hakamata, Y., Lissek, S., Bar-Haim, Y., Britton, J. C., Fox, N. A., Leibenluft, E., .... Pine, D. S. (2010). Attention bias modification treatment: a meta-analysis toward the establishment of novel treatment for anxiety. Biological Psychiatry, 68(11), 982–990.  https://doi.org/10.1016/j.biopsych.2010.07.021.
  46. Halldorsson, B., & Creswell, C. (2017). Social anxiety in pre-adolescent children: what do we know about maintenance? Behaviour Research and Therapy, 99, 19–36.  https://doi.org/10.1016/j.brat.2017.08.013.Google Scholar
  47. Hallion, L. S., & Ruscio, A. M. (2011). A meta-analysis of the effect of cognitive bias modification on anxiety and depression. Psychological Bulletin, 137(6), 940–958.  https://doi.org/10.1037/a0024355.Google Scholar
  48. Heeren, A., Reese, H. E., McNally, R. J., & Philippot, P. (2012). Attention training toward and away from threat in social phobia: effects on subjective, behavioral, and physiological measures of anxiety. Behaviour Research and Therapy, 50(1), 30–39.  https://doi.org/10.1016/j.brat.2011.10.005.Google Scholar
  49. Heeren, A., Mogoase, C., Philippot, P., & McNally, R. J. (2015a). Attention bias modification for social anxiety: a systematic review and meta-analysis. Clinical Psychology Review, 40, 76–90.  https://doi.org/10.1016/j.cpr.2015.06.001.Google Scholar
  50. Heeren, A., Philippot, P., & Koster, E. H. W. (2015b). Impact of the temporal stability of preexistent attentional bias for threat on its alteration through attention bias modification. Journal of Behavior Therapy and Experimental Psychiatry, 49(Part A), 69–75.  https://doi.org/10.1016/j.jbtep.2014.10.012.Google Scholar
  51. Heimberg, R. G., Horner, K. J., Juster, H. R., Safren, S. A., Brown, E. J., Schneier, F. R., & Liebowitz, M. R. (1999). Psychometric properties of the Liebowitz social anxiety scale. Psychological Medicine, 29(1), 199–212.Google Scholar
  52. Henderson, H. A., Pine, D. S., & Fox, N. A. (2015). Behavioral inhibition and developmental risk: a dual-processing perspective. Neuropsychopharmacology, 40(1), 207–224.  https://doi.org/10.1038/npp.2014.189.Google Scholar
  53. Hertel, P. T., & Mathews, A. (2011). Cognitive bias modification: past perspectives, current findings, and future applications. Perspectives on Psychological Science, 6(6), 521–536.  https://doi.org/10.1177/1745691611421205.Google Scholar
  54. Huizinga, M., Dolan, C. V., & van der Molen, M. W. (2006). Age-related change in executive function: developmental trends and a latent variable analysis. Neuropsychologia, 44(11), 2017–2036.  https://doi.org/10.1016/j.neuropsychologia.2006.01.010.Google Scholar
  55. Hwang, K., Velanova, K., & Luna, B. (2010). Strengthening of top-down frontal cognitive control networks underlying the development of inhibitory control: a functional magnetic resonance imaging effective connectivity study. Journal of Neuroscience, 30(46), 15535–15545.  https://doi.org/10.1523/JNEUROSCI.2825-10.2010.Google Scholar
  56. Hwang, S., White, S. F., Nolan, Z. T., Sinclair, S., & Blair, R. J. (2014). Neurodevelopmental changes in the responsiveness of systems involved in top down attention and emotional responding. Neuropsychologia, 62, 277–285.  https://doi.org/10.1016/j.neuropsychologia.2014.08.003.Google Scholar
  57. Jones, E. B., & Sharpe, L. (2017). Cognitive bias modification: a review of meta-analyses. Journal of Affective Disorders, 223, 175–183.  https://doi.org/10.1016/j.jad.2017.07.034.Google Scholar
  58. Karbach, J., & Unger, K. (2014). Executive control training from middle childhood to adolescence. Frontiers in Psychology, 5.  https://doi.org/10.3389/Fpsyg.2014.00390.
  59. Kashdan, T. B., & Herbert, J. D. (2001). Social anxiety disorder in childhood and adolescence: current status and future directions. Clinical Child and Family Psychology Review, 4(1), 37–61.Google Scholar
  60. Kazdin, A. E. (2017). Addressing the treatment gap: a key challenge for extending evidence-based psychosocial interventions. Behaviour Research and Therapy, 88, 7–18.  https://doi.org/10.1016/j.brat.2016.06.004.Google Scholar
  61. Klingberg, T. (2010). Training and plasticity of working memory. Trends in Cognitive Sciences, 14(7), 317–324.  https://doi.org/10.1016/j.tics.2010.05.002.Google Scholar
  62. Konen, T., & Karbach, J. (2015). The benefits of looking at intraindividual dynamics in cognitive training data. Frontiers in Psychology, 6.  https://doi.org/10.3389/Fpsyg.2015.00615.
  63. Lazarov, A., Abend, R., Seidner, S., Pine, D. S., & Bar-Haim, Y. (2017). The effects of training contingency awareness during attention bias modification on learning and stress reactivity. Behavior Therapy, 48(5), 638–650.  https://doi.org/10.1016/j.beth.2017.03.002.Google Scholar
  64. LeDoux, J. E., & Pine, D. S. (2016). Using neuroscience to help understand fear and anxiety: a two-system framework. American Journal of Psychiatry, 173(11), 1083–1093.  https://doi.org/10.1176/appi.ajp.2016.16030353.Google Scholar
  65. Leigh, E., & Clark, D. M. (2018). Understanding social anxiety disorder in adolescents and improving treatment outcomes: applying the cognitive model of Clark and Wells (1995). Clinical Child and Family Psychology Review, 21, 388–414.  https://doi.org/10.1007/s10567-018-0258-5.Google Scholar
  66. Liebowitz, M. R. (1987). Social phobia. Modern Problems of Pharmacopsychiatry, 22, 141–173.Google Scholar
  67. Linetzky, M., Pergamin-Hight, L., Pine, D. S., & Bar-Haim, Y. (2015). Quantitative evaluation of the clinical efficacy of attention bias modification treatment for anxiety disorders. Depression and Anxiety, 32(6), 383–391.  https://doi.org/10.1002/da.22344.Google Scholar
  68. Lovden, M., Brehmer, Y., Li, S. C., & Lindenberger, U. (2012). Training-induced compensation versus magnification of individual differences in memory performance. Frontiers in Human Neuroscience, 6, 141.  https://doi.org/10.3389/fnhum.2012.00141.Google Scholar
  69. Lowther, H., & Newman, E. (2014). Attention bias modification (ABM) as a treatment for child and adolescent anxiety: a systematic review. Journal of Affective Disorders, 168, 125–135.  https://doi.org/10.1016/j.jad.2014.06.051.Google Scholar
  70. Luna, B., Velanova, K., & Geier, C. F. (2008). Development of eye-movement control. Brain and Cognition, 68(3), 293–308.  https://doi.org/10.1016/j.bandc.2008.08.019.Google Scholar
  71. Luna, B., Padmanabhan, A., & O'Hearn, K. (2010). What has fMRI told us about the development of cognitive control through adolescence? Brain and Cognition, 72(1), 101–113.  https://doi.org/10.1016/j.bandc.2009.08.005.Google Scholar
  72. Lyneham, H. J., Abbott, M. J., & Rapee, R. M. (2007). Interrater reliability of the anxiety disorders interview schedule for DSM-IV: child and parent version. Journal of the American Academy of Child and Adolescent Psychiatry, 46(6), 731–736.  https://doi.org/10.1097/chi.0b013e318046a09.Google Scholar
  73. MacLeod, C., & Clarke, P. J. (2015). The attentional bias modification approach to anxiety intervention. Clinical Psychological Science, 3(1), 58–78.  https://doi.org/10.1177/2167702614560749.Google Scholar
  74. MacLeod, C., & Mathews, A. (2012). Cognitive bias modification approaches to anxiety. Annual Review of Clinical Psychology, 8, 189–217.  https://doi.org/10.1146/annurev-clinpsy-032511-143052.Google Scholar
  75. MacLeod, C., Mathews, A., & Tata, P. (1986). Attentional bias in emotional disorders. Journal of Abnormal Psychology, 95(1), 15–20.Google Scholar
  76. MacLeod, C., Koster, E. H. W., & Fox, E. (2009). Whither cognitive bias modification research? Commentary on the special section articles. Journal of Abnormal Psychology, 118(1), 89–99.  https://doi.org/10.1037/A0014878.Google Scholar
  77. Mathews, A., & MacLeod, C. (2002). Induced processing biases have causal effects on anxiety. Cognition & Emotion, 16(3), 331–354.  https://doi.org/10.1080/02699930143000518.Google Scholar
  78. Maybery, M., Taylor, M., & O’Brien-Malone, A. (1995). Implicit learning: sensitive to age but not IQ. Australian Journal of Psychology, 47(1), 8–17.Google Scholar
  79. Mogoase, C., David, D., & Koster, E. H. (2014). Clinical efficacy of attentional bias modification procedures: an updated meta-analysis. Journal of Clinical Psychology, 70(12), 1133–1157.  https://doi.org/10.1002/jclp.22081.Google Scholar
  80. Naim, R., Kiviti, Y., Bar-Haim, Y., & Huppert, J. (2018). Attention and interpretation bias modification training for social anxiety: a randomized clinical trial of efficacy and synergy. Journal of Behavior Therapy and Experimental Psychiatry, 59, 19–30.  https://doi.org/10.1016/j.jbtep.2017.10.006.Google Scholar
  81. Pergamin-Hight, L., Naim, R., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., & Bar-Haim, Y. (2015). Content specificity of attention bias to threat in anxiety disorders: a meta-analysis. Clinical Psychology Review, 35, 10–18.  https://doi.org/10.1016/j.cpr.2014.10.005.Google Scholar
  82. Pergamin-Hight, L., Pine, D. S., Fox, N. A., & Bar-Haim, Y. (2016). Attention bias modification for youth with social anxiety disorder. Journal of Child Psychology and Psychiatry, 57(11), 1317–1325.  https://doi.org/10.1111/jcpp.12599.Google Scholar
  83. Price, R. B., Kuckertz, J. M., Siegle, G. J., Ladouceur, C. D., Silk, J. S., Ryan, N. D., ... Amir, N. (2015). Empirical recommendations for improving the stability of the dot-probe task in clinical research. Psychological Assessment, 27(2), 365–376.  https://doi.org/10.1037/pas0000036.
  84. Price, R. B., Wallace, M., Kuckertz, J. M., Amir, N., Graur, S., Cummings, L., ... Bar-Haim, Y. (2016). Pooled patient-level meta-analysis of children and adults completing a computer-based anxiety intervention targeting attentional bias. Clinical Psychology Review, 50, 37–49.  https://doi.org/10.1016/j.cpr.2016.09.009.
  85. Rahmani, E., & Boren, S. A. (2012). Videogames and health improvement: a literature review of randomized controlled trials. Games for Health Journal, 1(5), 331–341.  https://doi.org/10.1089/g4h.2012.0031.Google Scholar
  86. Salum, G. A., Mogg, K., Bradley, B. P., Gadelha, A., Pan, P., Tamanaha, A. C., ... Pine, D. S. (2013). Threat bias in attention orienting: evidence of specificity in a large community-based study. Psychological Medicine, 43(4), 733–745.  https://doi.org/10.1017/S0033291712001651.
  87. Shechner, T., & Bar-Haim, Y. (2016). Threat monitoring and attention-bias modification in anxiety and stress-related disorders. Current Directions in Psychological Science, 25(6), 431–437.  https://doi.org/10.1177/0963721416664341.Google Scholar
  88. Shechner, T., Hong, M., Britton, J. C., Pine, D. S., & Fox, N. A. (2014a). Fear conditioning and extinction across development: evidence from human studies and animal models. Biological Psychology, 100, 1–12.  https://doi.org/10.1016/j.biopsycho.2014.04.001.Google Scholar
  89. Shechner, T., Rimon-Chakir, A., Britton, J. C., Lotan, D., Apter, A., Bliese, P. D., ... Bar-Haim, Y. (2014b). Attention Bias modification treatment augmenting effects on cognitive behavioral therapy in children with anxiety: Randomized controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry, 53(1), 61–71.  https://doi.org/10.1016/j.jaac.2013.09.016.
  90. Sheehan, D. V., Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E., ... Dunbar, G. C. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59(Suppl 20), 22–33;quiz 34–57.Google Scholar
  91. Shin, E., Lee, H., Yoo, S. A., & Chong, S. C. (2015). Training improves the capacity of visual working memory when it is adaptive, individualized, and targeted. PLoS One, 10(4).  https://doi.org/10.1371/journal.pone.0121702.
  92. Spence, S. H., Donovan, C., & Brechman-Toussaint, M. (2000). The treatment of childhood social phobia: the effectiveness of a social skills training-based, cognitive-behavioural intervention, with and without parental involvement. Journal of Child Psychology and Psychiatry and Allied Disciplines, 41(6), 713–726.  https://doi.org/10.1111/1469-7610.00659.Google Scholar
  93. Stein, M. B., & Kean, Y. M. (2000). Disability and quality of life in social phobia: epidemiologic findings. American Journal of Psychiatry, 157(10), 1606–1613.  https://doi.org/10.1176/appi.ajp.157.10.1606.Google Scholar
  94. Stein, M. B., & Stein, D. J. (2008). Social anxiety disorder. Lancet, 371(9618), 1115–1125.  https://doi.org/10.1016/S0140-6736(08)60488-2.Google Scholar
  95. Thomas, K. M., Hunt, R. H., Vizueta, N., Sommer, T., Durston, S., Yang, Y., & Worden, M. S. (2004). Evidence of developmental differences in implicit sequence learning: an fMRI study of children and adults. Journal of Cognitive Neuroscience, 16(8), 1339–1351.  https://doi.org/10.1162/0898929042304688.Google Scholar
  96. Tottenham, N., Tanaka, J. W., Leon, A. C., McCarry, T., Nurse, M., Hare, T. A., ... Nelson, C. (2009). The NimStim set of facial expressions: judgments from untrained research participants. Psychiatry Research, 168(3), 242–249.  https://doi.org/10.1016/j.psychres.2008.05.006.
  97. Vidal, F., Meckler, C., & Hasbroucq, T. (2015). Basics for sensorimotor information processing: some implications for learning. Frontiers in Psychology, 6, 33.  https://doi.org/10.3389/fpsyg.2015.00033.Google Scholar
  98. Wang, Z., Whiteside, S. P. H., Sim, L., Farah, W., Morrow, A. S., Alsawas, M., ... Murad, M. H. (2017). Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: A systematic review and meta-analysis. JAMA Pediatrics, 171(11), 1049–1056.  https://doi.org/10.1001/jamapediatrics.2017.3036.
  99. Waters, A. M., Pittaway, M., Mogg, K., Bradley, B. P., & Pine, D. S. (2013). Attention training towards positive stimuli in clinically anxious children. Developmental Cognitive Neuroscience, 4, 77–84.  https://doi.org/10.1016/j.dcn.2012.09.004.Google Scholar
  100. Waters, A. M., Zimmer-Gembeck, M. J., Craske, M. G., Pine, D. S., Bradley, B. P., & Mogg, K. (2015). Look for good and never give up: a novel attention training treatment for childhood anxiety disorders. Behaviour Research and Therapy, 73, 111–123.  https://doi.org/10.1016/j.brat.2015.08.005.Google Scholar
  101. Weisberg, R. B., Dyck, I., Culpepper, L., & Keller, M. B. (2007). Psychiatric treatment in primary care patients with anxiety disorders: a comparison of care received from primary care providers and psychiatrists. American Journal of Psychiatry, 164(2), 276–282.  https://doi.org/10.1176/ajp.2007.164.2.276.Google Scholar
  102. Weisz, J. R., Kuppens, S., Ng, M. Y., Eckshtain, D., Ugueto, A. M., Vaughn-Coaxum, R., ... Fordwood, S. R. (2017). What five decades of research tells us about the effects of youth psychological therapy: a multilevel meta-analysis and implications for science and practice. American Psychologist, 72(2), 79–117.  https://doi.org/10.1037/a0040360.
  103. White, L. K., Sequeira, S., Britton, J. C., Brotman, M. A., Gold, A. L., Berman, E., ... Pine, D. S. (2017). Complementary features of attention bias modification therapy and cognitive-behavioral therapy in pediatric anxiety disorders. American Journal of Psychiatry.  https://doi.org/10.1176/appi.ajp.2017.16070847.
  104. Wood, J. J., Piacentini, J. C., Bergman, R. L., McCracken, J., & Barrios, V. (2002). Concurrent validity of the anxiety disorders section of the anxiety disorders interview schedule for DSM-IV: child and parent versions. Journal of Clinical Child and Adolescent Psychology, 31(3), 335–342.  https://doi.org/10.1207/153744202760082595.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Rany Abend
    • 1
    Email author
  • Reut Naim
    • 2
  • Lee Pergamin-Hight
    • 2
  • Nathan A. Fox
    • 3
  • Daniel S. Pine
    • 1
  • Yair Bar-Haim
    • 2
  1. 1.Section on Development and Affective NeuroscienceNational Institute of Mental HealthBethesdaUSA
  2. 2.School of Psychological SciencesTel Aviv UniversityTel AvivIsrael
  3. 3.Department of Human Development and Quantitative MethodologyUniversity of MarylandCollege ParkUSA

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