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Conjunctival melanoma in patients with xeroderma pigmentosum: a series of four cases

  • Varshitha Hemanth Vasanthapuram
  • Swathi KalikiEmail author
Original Paper
  • 15 Downloads

Abstract

Purpose

To study the demographic features, treatment, histopathology, and outcomes in patients of xeroderma pigmentosum (XP) with conjunctival melanoma.

Methods

Retrospective case series.

Results

The median age at presentation was 18 years (range 9–30 years). There were three females and one male patient presenting with a median duration of symptoms of 3 months (range 1–60 months). The tumor was located in the bulbar conjunctiva in all 4 patients. All patients had corneal involvement by the tumor. The median tumor basal diameter was 7 mm (range 4–15 mm). Wide tumor excisional biopsy with alcohol keratoepithelectomy, cryotherapy to the free margins, and amniotic membrane grafting was done in three patients. One patient underwent orbital exenteration for extensive tumor. One patient also received adjuvant plaque brachytherapy for microscopic residual tumor. Over a median follow-up of 22 months (range 2–101 months), there were no recurrences, metastasis, or death.

Conclusion

Conjunctival melanoma in XP is rare and manifests at a younger age.

Keywords

Eye Conjunctiva Tumor Melanoma Xeroderma pigmentosum 

Notes

Acknowledgements

Support provided by the Operation Eyesight Universal Institute for Eye Cancer (SK) and Hyderabad Eye Research Foundation (SK), Hyderabad, India. The funders had no role in the preparation, review, or approval of the manuscript.

Funding

None to disclose.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal participants

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants or parents/guardians included in the study.

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Copyright information

© Springer Nature B.V. 2020

Authors and Affiliations

  1. 1.Operation Eyesight Universal Institute for Eye Cancer (VHV, SK)L V Prasad Eye InstituteHyderabadIndia

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