International Ophthalmology

, Volume 39, Issue 11, pp 2449–2457 | Cite as

Macular spectral-domain optical coherence tomography values and correlations in healthy children

  • Andrea Passani
  • Angela Tindara Sframeli
  • Chiara Posarelli
  • Domenico Lisi
  • Gianluca Guidi
  • Giamberto Casini
  • Antonio Ferreras
  • Michele FigusEmail author
Original Paper



The aim of this study is to investigate potential correlations between age, gender, spherical equivalent and optical coherence tomography (OCT) retinal parameters among healthy children.


A macular spectral-domain OCT was performed in all patients using a Spectralis® OCT device, and the macular thickness and volume of each of the early treatment diabetic retinopathy study (ETDRS) subfields were analysed.


Ninety-four children were enrolled. Mean central macular thickness was 274.968 ± 18.28 µm, while mean central macular volume was 0.216 mm3. Statistical analysis showed a significant correlation between the factor age and central macular thickness (F(3,90) = 4.96, p = 0.003, η2 = 0.14) and central macular volume (F(3,90) = 4.98, p = 0.003, η2 = 0.14). Statistical analysis showed a significant correlation between the factor gender and macular thickness/volume of several ETDRS subfields. A significant correlation between refractive error and macular thickness/volume was also noted.


This study shows significant correlations between macular thickness/volume and the factors age, gender and spherical equivalent. Paediatric spectral-domain optical coherence tomography ranges need further investigations since many significant correlations are still to be confirmed.


Optical coherence tomography Paediatric ophthalmology Retinal imaging Healthy children OCT values 



The authors of this manuscript have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Availability of data and materials

All the data used and/or analysed during the current study are available from the corresponding author on reasonable request.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Università di Pisa-Dipartimento di patologia chirurgica medica, molecolare e dell’area criticaPisaItaly
  2. 2.Azienda Ospedaliero-Universitaria PisanaPisaItaly
  3. 3.Miguel Servet University HospitalUniversitad de ZaragozaZaragozaSpain

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