International Ophthalmology

, Volume 39, Issue 10, pp 2401–2406 | Cite as

Hydration of small leaking corneal perforations with cefuroxime

  • Gilad AllonEmail author
  • Yinon Shapira
  • Itzchak Beiran
  • Eytan Z. Blumenthal
Original Paper



To describe a new technique for sealing small corneal perforations after penetrating trauma.


Corneal perforations in six eyes were sealed using a stromal cefuroxime hydration technique. This technique is identical to the current method used to seal leaking incisions upon completion of cataract surgery except for the use of cefuroxime instead of balanced salt solution. Additionally, cefuroxime was intentionally injected into the anterior chamber. A therapeutic contact lens was used after the hydration. Comparison was made in eight eyes with small traumatic corneal perforation that was sealed using therapeutic contact lenses without hydration.


This novel technique was applied in six cases, with leakage stopping immediately following hydration in each of these eyes. In cases presenting with a shallow or flat anterior chamber, this maneuver produced immediate reformation of the chamber. Of note, the corneal scars after hydration were minimal with little effect on visual acuity. When compared to eyes with small corneal perforations which were sealed with therapeutic contact lenses without hydration, all cases that were hydrated with cefuroxime were sealed immediately, as opposed to cases treated without hydration. Furthermore, the eyes that underwent hydration with cefuroxime had a worse average visual acuity on admission, a better average visual acuity 1 month post-trauma, and a shorter average length of hospitalization.


This new technique offers five major advantages: (1) Immediate sealing of the corneal perforation is achieved. (2) Definitive treatment can be achieved at the slit lamp. (3) Since neither stitches nor glue is applied, healing is achieved with minimal scarring and discomfort. (4) Little equipment is required. (5) Injection of cefuroxime into the anterior chamber provides prophylaxis against infection.


Corneal perforation Corneal hydration Cefuroxime Corneal scar 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Gilad Allon
    • 1
    Email author
  • Yinon Shapira
    • 1
  • Itzchak Beiran
    • 1
  • Eytan Z. Blumenthal
    • 1
  1. 1.Department of OphthalmologyRambam Healthcare CampusHaifaIsrael

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