International Ophthalmology

, Volume 39, Issue 9, pp 2129–2136 | Cite as

BKC and CME: Is benzalkonium chloride hindering our efforts to achieve the desired postoperative visual acuity?

  • Harinder Singh Sethi
  • Sugourab Das
  • Mayuresh P. NaikEmail author
  • Rajshekhar Vemparala
Original Paper



To evaluate and compare the change in postoperative central macular thickness in patients receiving benzalkonium chloride (BKC)-preserved and BKC-free medications after uneventful phacoemulsification.


V.M.M.C & Safdarjung Hospital, New Delhi (a tertiary health care hospital).

Study design

Prospective randomized comparative observational study.

Materials and methods

Once patients were selected, the baseline standard ophthalmic examination was done. Sample size: 140 eyes were enrolled and randomly divided into two groups. (a) Group I: receive BKC-preserved topical medications and (b) Group II: receive BKC-free topical medications of same constituents postoperatively. Group I patients received topical BKC-preserved moxifloxacin 0.5% + dexamethasone 0.1% eye drops six times a day, timolol maleate 0.5% twice daily, tropicamide 0.8% + phenylephrine 5% once a day for 6 weeks, and Group II received same BKC-free topical eye drops for 6 weeks. Postoperatively, the patients were reviewed at day 1, week 1, week 6 for same parameters.


Quantitative variables: paired and unpaired t test. p value < 0.05 was considered statistically significant.


The mean CMT in μm at 1 week in Group I was 269.39 ± 14.56 and in Group II was 270.04 ± 6.56. The mean CMT in µm at 6 weeks in Group I was 270.39 ± 17.18 and in Group II was 270.90 ± 7.00.


Neither do BKC-preserved topical medications have any independent role in increasing the central macular thickness after uneventful surgery nor do they have any role in causing pseudophakic CME.


BKC CME Phacoemulsification 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Harinder Singh Sethi
    • 1
  • Sugourab Das
    • 1
  • Mayuresh P. Naik
    • 1
    Email author
  • Rajshekhar Vemparala
    • 1
  1. 1.Department of OphthalmologyV.M.M.C & Safdarjung HospitalNew DelhiIndia

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