BKC and CME: Is benzalkonium chloride hindering our efforts to achieve the desired postoperative visual acuity?
- 41 Downloads
To evaluate and compare the change in postoperative central macular thickness in patients receiving benzalkonium chloride (BKC)-preserved and BKC-free medications after uneventful phacoemulsification.
V.M.M.C & Safdarjung Hospital, New Delhi (a tertiary health care hospital).
Prospective randomized comparative observational study.
Materials and methods
Once patients were selected, the baseline standard ophthalmic examination was done. Sample size: 140 eyes were enrolled and randomly divided into two groups. (a) Group I: receive BKC-preserved topical medications and (b) Group II: receive BKC-free topical medications of same constituents postoperatively. Group I patients received topical BKC-preserved moxifloxacin 0.5% + dexamethasone 0.1% eye drops six times a day, timolol maleate 0.5% twice daily, tropicamide 0.8% + phenylephrine 5% once a day for 6 weeks, and Group II received same BKC-free topical eye drops for 6 weeks. Postoperatively, the patients were reviewed at day 1, week 1, week 6 for same parameters.
Quantitative variables: paired and unpaired t test. p value < 0.05 was considered statistically significant.
The mean CMT in μm at 1 week in Group I was 269.39 ± 14.56 and in Group II was 270.04 ± 6.56. The mean CMT in µm at 6 weeks in Group I was 270.39 ± 17.18 and in Group II was 270.90 ± 7.00.
Neither do BKC-preserved topical medications have any independent role in increasing the central macular thickness after uneventful surgery nor do they have any role in causing pseudophakic CME.
KeywordsBKC CME Phacoemulsification
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 2.Gass JDM, Norton EWD (1966) Fluorescein studies of patients with macular edema and papilloedema following cataract extraction. Trans Am Ophthalmol Soc 64:232–249Google Scholar
- 7.Grant W (1974) Toxicology of the eye. Thomas, SpringfieldGoogle Scholar
- 11.Hudes GR, Li WY, Rockey JH, White P (1988) Prostacyclin is the major prostaglandin synthesized by bovine retinal capillary pericytes in culture. Invest Ophthalmol Vis Sci 29:1511–1516Google Scholar
- 12.Flach AJ (1998) The incidence, pathogenesis and treatment of cystoid macular edema following cataract surgery. Trans Am Ophthalmol Soc 96:557–634Google Scholar
- 13.Tsilimbaris MK, Tsika C, Diakonis V, Karavitaki A, Pallikaris I (2013) Macular edema and cataract surgery, in cataract surgery. In: Zaid F (ed) Cataract surgery. InTech. ISBN 978-953-51-0975-4Google Scholar
- 15.Sahin M, Cingu AK, Gozum N (2013) Evaluation of cystoid macular edema using optical coherence tomography and fundus autofluorescence after uncomplicated phacoemulsification surgery. J Ophthalmol 2013:376013Google Scholar
- 24.Arora S (2012) OCT provides insights into retinal changes after uneventful cataract surgery. Ocul Surg News. Retrieved from https://www.healio.com/ophthalmology/retina-vitreous/news/print/ocular-surgery-news-europe-edition/%7B57b2f345-acb4-4f48-88bb-18f613f3f0dd%7D/oct-provides-insights-into-retinal-changes-after-uneventful-cataract-surgery