International Ophthalmology

, Volume 39, Issue 9, pp 2103–2109 | Cite as

Efficacy of fixation of the amniotic membrane on a symblepharon ring with continuous suturing in acute ocular chemical burn patients

  • Cezmi DoganEmail author
  • Osman Sevki Arslan
  • Akif Ozdamar
  • Burak Mergen
  • Ahmet Murat Sarici
  • Guzin Iskeleli
Original Paper



To describe a modified non-traumatic amniotic membrane transplantation (AMT) technique and evaluating its efficiency for the ocular surface injury after chemical burn were aimed.


Twenty eyes of 20 patients (F: 6, M: 14) with acute chemical burn for whom modified non-traumatic AMT was utilized were evaluated retrospectively. In this technique, amniotic membrane (AM) was fixated onto a symblepharon ring with continuous suturing. The healing time of the corneal epithelial defect due to ocular surface chemical injury and melting duration of AM were evaluated. Development of infection or symblepharon, recurrence or persistence of epithelial defect, corneal perforation and the ring falling out with AM were evaluated as complications.


Mean age of the patients was 24.7 ± 11.7 years old (14 months–40 years). Mean duration of applying the non-traumatic AMT after contact with the chemical agent was 8.4 ± 6.2 days (2–21 days). The mean duration of the epithelial defect healing was 27.8 ± 8.8 days (11–40 days) in the grade II, III, and IV (n = 12) cases, while in the grade V and VI (n = 8) cases, a persistent epithelial defect developed, and the mean duration of the epithelial defect healing was 83 ± 23.1 days (42–120 days) (p = 0.0002). The mean melting duration of the AM was 22.7 ± 10 days (10–42 days).


By using this modified AMT technique, AM can be utilized efficiently, easily, and non-traumatically in every center for the treatment of the ocular surface injury due to chemical burn.


Amniotic membrane Ocular surface Symblepharon ring Chemical burn 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Ophthalmology, Cerrahpasa Medical FacultyIstanbul UniversityIstanbulTurkey

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