Predictive value of spectral-domain optical coherence tomography features in assessment of visual prognosis in eyes with acute welding arc maculopathy
- 21 Downloads
To observe spectral-domain optical coherence tomography (SD-OCT) features and to determine whether baseline OCT features can be used as predictors of visual acuity outcome in eyes with acute welding arc maculopathy.
This retrospective study enrolled twenty-two eyes of eleven subjects with acute welding arc maculopathy. All subjects were evaluated by SD-OCT at baseline and final visit. The involved parameters included best-corrected visual acuity (BCVA), central macular thickness (CMT), the length of ellipsoid zone (EZ) defects, the greatest linear dimension (GLD) of outer retinal lesions, EZ reflectivity and relative EZ reflectivity (defined as the ratio of EZ reflectivity to retinal pigment epithelium reflectivity on OCT).
Acute welding arc maculopathy was presented as abnormal hyperreflectivity, hyporeflectivity and defects of outer retinal layer in fovea on OCT. Compared with baseline, BCVA improved significantly accompanied by decreased GLD of outer retinal lesions and the length of EZ defects at final visit (P = 0.0004, P < 0.0001 and P < 0.0001, respectively). No significant changes were shown on CMT (P = 0.248). In multivariate regression analysis, final BCVA was associated with baseline BCVA and the length of EZ defects (P = 0.012 and P = 0.045, respectively). However, EZ reflectivity and relative EZ reflectivity were not associated with final BCVA (P > 0.05).
In conclusion, SD-OCT images clearly reveal morphological changes in outer retinal layer in acute welding arc maculopathy. The baseline BCVA and length of EZ defects are the strongest predictors of final BCVA.
KeywordsWelding arc maculopathy Spectral-domain optical coherence tomography Ellipsoid zone Visual acuity
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The study has been approved by the local institutional ethics committee of Jinan Mingshui Eye Hospital and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.
- 1.Houly JR, Veloso CE, Passos E, Nehemy MB (2017) Quantitative analysis of external limiting membrane, ellipsoid zone and interdigitation zone defects in patients with macular holes. Graefes Arch Clin Exp Ophthalmol 255(7):1297–1306. https://doi.org/10.1007/s00417-017-3636-7 CrossRefPubMedGoogle Scholar
- 9.Flores M, Debellemaniere G, Bully A, Meillat M, Tumahai P, Delbosc B, Saleh M (2015) Reflectivity of the outer retina on spectral-domain optical coherence tomography as a predictor of photoreceptor cone density. Am J Ophthalmol 160(3):588–595 e582. https://doi.org/10.1016/j.ajo.2015.06.008 CrossRefPubMedGoogle Scholar
- 12.Srinivasan VJ, Monson BK, Wojtkowski M, Bilonick RA, Gorczynska I, Chen R, Duker JS, Schuman JS, Fujimoto JG (2008) Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci 49(4):1571–1579. https://doi.org/10.1167/iovs.07-0838 CrossRefPubMedPubMedCentralGoogle Scholar
- 13.Oster SF, Mojana F, Brar M, Yuson RM, Cheng L, Freeman WR (2010) Disruption of the photoreceptor inner segment/outer segment layer on spectral domain-optical coherence tomography is a predictor of poor visual acuity in patients with epiretinal membranes. Retina 30(5):713–718. https://doi.org/10.1097/IAE.0b013e3181c596e3 CrossRefPubMedGoogle Scholar
- 14.Maheshwary AS, Oster SF, Yuson RM, Cheng L, Mojana F, Freeman WR (2010) The association between percent disruption of the photoreceptor inner segment-outer segment junction and visual acuity in diabetic macular edema. Am J Ophthalmol 150(1):63–67 e61. https://doi.org/10.1016/j.ajo.2010.01.039 CrossRefPubMedPubMedCentralGoogle Scholar
- 16.Wolf-Schnurrbusch UE, Ghanem R, Rothenbuehler SP, Enzmann V, Framme C, Wolf S (2011) Predictors of short-term visual outcome after anti-VEGF therapy of macular edema due to central retinal vein occlusion. Invest Ophthalmol Vis Sci 52(6):3334–3337. https://doi.org/10.1167/iovs.10-6097 CrossRefPubMedGoogle Scholar
- 18.Barthelmes D, Sutter FK, Kurz-Levin MM, Bosch MM, Helbig H, Niemeyer G, Fleischhauer JC (2006) Quantitative analysis of OCT characteristics in patients with achromatopsia and blue-cone monochromatism. Invest Ophthalmol Vis Sci 47(3):1161–1166. https://doi.org/10.1167/iovs.05-0783 CrossRefPubMedGoogle Scholar
- 19.Mataftsi A, Schorderet DF, Chachoua L, Boussalah M, Nouri MT, Barthelmes D, Borruat FX, Munier FL (2007) Novel TULP1 mutation causing leber congenital amaurosis or early onset retinal degeneration. Invest Ophthalmol Vis Sci 48(11):5160–5167. https://doi.org/10.1167/iovs.06-1013 CrossRefPubMedGoogle Scholar