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International Ophthalmology

, Volume 39, Issue 4, pp 813–819 | Cite as

Retinal vessel diameter obtained by optical coherence tomography is spared in Parkinson’s disease

  • Duygu Gulmez SevimEmail author
  • Metin Unlu
  • Serap Sonmez
  • Murat Gultekin
  • Cagatay Karaca
  • Ayse Ozturk Oner
Original Paper

Abstract

Purpose

To define the alterations in retinal vessel diameter in Parkinson’s disease (PD) by optical coherence tomography (OCT).

Methods

This is a case-control study including 41 eyes of 41 patients with diagnosis of PD and 35 eyes of 35 age- and sex-matched control subjects. All subjects underwent complete neurological and ophthalmological examinations before measurements. Retinal vessel diameters and peripapillary retinal nerve fiber layer (pRNFL) thicknesses were evaluated with spectral domain OCT (SD-OCT) with a circular scan centered at the optic disc. The diameters of the superior nasal and temporal arteries and veins, and inferior nasal and temporal arteries and veins were measured and then compared between the groups. Correlations with the duration of the disease, usage of levodopa, and pRNFL thicknesses between retinal vessel diameters were examined with Pearson and Spearman correlation analysis.

Results

Average pRNFL thickness is significantly decreased in PD compared to age- and sex-matched controls (p < 0.05). At all measurement points, retinal artery diameter measurements were decreased in the PD group compared to controls, but the differences did not reach statistical significance. Diameters of the retinal veins also did not show any significant difference in the PD and control groups. Superior temporal artery diameter was significantly decreased in patients using levodopa compared to nonusers (p = 0.022). There were no statistically significant correlations between pRNFL thicknesses or disease duration with retinal vessel diameters in PD group.

Conclusions

Parkinson’s disease does not seem to have an impact on the retinal vessel diameters obtained by SD-OCT.

Keywords

Optical coherence tomography Parkinson’s disease Retina Retinal nerve fiber layer Retinal vessel diameter 

Notes

Acknowledgements

The study was approved by the Erciyes University Clinical Research Ethics Committee (No: 2016/24, date: August 1, 2016).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest. We confirm that we had full access to all data and we took final responsibility for decision to submit.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of OphthalmologyErciyes University Faculty of MedicineKayseriTurkey
  2. 2.Department of NeurologyErciyes University Faculty of MedicineKayseriTurkey

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