Influence of glaucoma surgery on the ocular surface using oculus keratograph
To investigate the influence of trabeculectomy and phacotrabeculectomy on the ocular surface.
Retrospective, case–control study.
Eighty-one samples without dry eyes were recruited and divided into three groups, including phacoemulsification group (N = 30) as control group, trabeculectomy group (N = 27) and phacotrabeculectomy group (N = 24) as study groups. Ocular surface parameters, including noninvasive keratograph first (NifBUT) and average (NiaBUT) tear film breakup time, tear meniscus height (TMH) and corneal fluorescein stain (CFS), were estimated preoperatively, at 3 days, 1 month and 3 months postoperatively using oculus keratograph.
No significant difference was observed in ocular surface parameters at baseline among three groups (p > 0.05). The magnitude of NifBUT and NiaBUT was reduced at 3 days and 1 month postoperatively in phacotrabeculectomy group, but greater than that in the other two groups (All p < 0.001). In all the groups, both the NifBUT and NiaBUT tended to recover at 1 and 3 months postoperatively, whereas both of them did not recover to baseline at 3 months postoperatively in trabeculectomy (NifBUT, p = 0.001; NiaBUT, p < 0.001) and phacotrabeculectomy group (NifBUT, p < 0.001; NiaBUT, p = 0.020). TMH was raised at 3 days postoperatively and restored to the baseline level at 1 and 3 months postoperatively for three groups (p > 0.05). CFS was elevated at 3 days postoperatively and different in recovery at 1 and 3 months postoperatively for three groups.
The influence of phacotrabeculectomy on ocular surface is worse than that of trabeculectomy for the short run and is not distinct different for a long time.
KeywordsGlaucoma Dry eye Ocular surface Breakup time Oculus keratograph
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
- 8.Bron AJ, Abelson MB, Ousler G, Pearce E, Tomlinson A, Yokoi N, Smith JA, Begley C, Caffery B, Nichols K, Schaumberg D (2007) Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop. Ocul Surf 5(2):108–152CrossRefGoogle Scholar
- 16.Liu W, Li H, Lu D et al (2010) The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. Mol Vis 16:2342–2346Google Scholar
- 22.Knop E, Knop N, Schirra F (2009) Meibomian glands. Part II: physiology, characteristics, distribution and function of meibomian oil. Ophthalmol Z Dtsch Ophthalmol Ges 106(10):884–892Google Scholar
- 24.Aguayo Bonniard A, Yeung JY, Chan CC, Birt CM (2016) Ocular surface toxicity from glaucoma topical medications and associated preservatives such as benzalkonium chloride (BAK). Exp Opin Drug Metab Toxicol 18:1–11Google Scholar