International Ophthalmology

, Volume 39, Issue 4, pp 949–956 | Cite as

Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis

  • Mohammad Hossein Jabbarpoor BonyadiEmail author
  • Mehdi Yaseri
  • Homayoun Nikkhah
  • Mortaza Bonyadi
  • Rahman Nazari
  • Masoud Soheilian



We designed this meta-analysis to pool studies which have analyzed both CFH (Y402H or I62V) and ARMS2 A69S in the same samples to compare the effect of CFH and ARMS2 in neovascular AMD.


Relevant studies identified and reviewed separately in order to select those for inclusion. Included studies had genotype data of studied groups for both ARMS2 A69S and CFH. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA. Funnel plot and Egger’s regression test used for evaluation of the possible publication bias.


Overall, we included 6676 neovascular AMD cases and 7668 controls. Pooled overall odds ratios (ORs) (95% CI) for neovascular AMD/control were ARMS2 A69S: OR = 2.35 (2.01–2.75) for GT versus GG; OR = 8.57 (6.91–10.64) for TT versus GG; CFH Y402H: OR = 1.94 (1.73–2.18) for CT versus TT; OR = 4.89 (3.96–6.05) for CC versus TT. ARMS2 A69S genotype OR/CFH Y402H genotype OR (homogeneous genotypes): Asia = 2.14, Europe: 1.87, America: 1.82, Middle East: 3.56, pooled: 1.75. ARMS2 A69S genotype OR/CFH Y402H genotype OR (heterogeneous genotypes): Asia = 0.93, Europe: 1.39, America: 2.06, Middle East: 1.20, pooled: 1.21. ARMS2 A69S risk genotypes have stronger predisposing effect on neovascular AMD compared to CFH Y402H risk genotypes.


Our inclusion criteria to select those studies which have analyzed the effect of these two loci in the same case-control samples showed much stronger effect of ARMS2 A69S in neovascular AMD compared to the CFH Y402H.


ARMS2/LOC387715 A69S CFH Y402H Wet-type age-related macular degeneration Meta-analysis 



Center of Excellence for Biodiversity sponsored this study. The sponsor had no role in the design or conduct of this research.

Compliance with ethical standards

Conflict of interest

There is no conflict of interest. No conflicting relationship exists for any author.

Ethical approval

This study adhered to the tenets of the declaration of Helsinki and is approved by the ethics committee of the Shahid Beheshti Medical University.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Mohammad Hossein Jabbarpoor Bonyadi
    • 1
    Email author
  • Mehdi Yaseri
    • 2
  • Homayoun Nikkhah
    • 1
  • Mortaza Bonyadi
    • 3
  • Rahman Nazari
    • 1
  • Masoud Soheilian
    • 1
  1. 1.Ocular Tissue Engineering Research Center, Ophthalmic Research CenterShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Biostatistics and EpidemiologyTehran University of Medical SciencesTehranIran
  3. 3.Faculty of Natural Sciences, Center of Excellence for BiodiversityUniversity of TabrizTabrizIran

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