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International Ophthalmology

, Volume 39, Issue 4, pp 949–956 | Cite as

Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis

  • Mohammad Hossein Jabbarpoor BonyadiEmail author
  • Mehdi Yaseri
  • Homayoun Nikkhah
  • Mortaza Bonyadi
  • Rahman Nazari
  • Masoud Soheilian
Review
  • 153 Downloads

Abstract

Purpose

We designed this meta-analysis to pool studies which have analyzed both CFH (Y402H or I62V) and ARMS2 A69S in the same samples to compare the effect of CFH and ARMS2 in neovascular AMD.

Methods

Relevant studies identified and reviewed separately in order to select those for inclusion. Included studies had genotype data of studied groups for both ARMS2 A69S and CFH. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA. Funnel plot and Egger’s regression test used for evaluation of the possible publication bias.

Results

Overall, we included 6676 neovascular AMD cases and 7668 controls. Pooled overall odds ratios (ORs) (95% CI) for neovascular AMD/control were ARMS2 A69S: OR = 2.35 (2.01–2.75) for GT versus GG; OR = 8.57 (6.91–10.64) for TT versus GG; CFH Y402H: OR = 1.94 (1.73–2.18) for CT versus TT; OR = 4.89 (3.96–6.05) for CC versus TT. ARMS2 A69S genotype OR/CFH Y402H genotype OR (homogeneous genotypes): Asia = 2.14, Europe: 1.87, America: 1.82, Middle East: 3.56, pooled: 1.75. ARMS2 A69S genotype OR/CFH Y402H genotype OR (heterogeneous genotypes): Asia = 0.93, Europe: 1.39, America: 2.06, Middle East: 1.20, pooled: 1.21. ARMS2 A69S risk genotypes have stronger predisposing effect on neovascular AMD compared to CFH Y402H risk genotypes.

Conclusion

Our inclusion criteria to select those studies which have analyzed the effect of these two loci in the same case-control samples showed much stronger effect of ARMS2 A69S in neovascular AMD compared to the CFH Y402H.

Keywords

ARMS2/LOC387715 A69S CFH Y402H Wet-type age-related macular degeneration Meta-analysis 

Notes

Funding

Center of Excellence for Biodiversity sponsored this study. The sponsor had no role in the design or conduct of this research.

Compliance with ethical standards

Conflict of interest

There is no conflict of interest. No conflicting relationship exists for any author.

Ethical approval

This study adhered to the tenets of the declaration of Helsinki and is approved by the ethics committee of the Shahid Beheshti Medical University.

References

  1. 1.
    Congdon N, O’Colmain B, Klaver CC et al (2004) Eye Diseases Prevalence Research Group. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122:477–485CrossRefGoogle Scholar
  2. 2.
    Bressler NM (2002) Early detection and treatment of neovascular age-related macular degeneration. J Am Board Fam Pract 15:142–152Google Scholar
  3. 3.
    Weeks DE, Conley YP, Tsai HJ et al (2004) Age-related maculopathy: a genome wide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am J Hum Genet 75:174–189CrossRefGoogle Scholar
  4. 4.
    Jakobsdottir J, Conley YP, Weeks DE et al (2005) Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet 77:389–407CrossRefGoogle Scholar
  5. 5.
    Jabbarpoor Bonyadi MH, Yaseri M, Bonyadi M et al (2016) Association of combined complement factor H Y402H and ARMS/LOC387715 A69S polymorphisms with age-related macular degeneration: a meta-analysis. Curr Eye Res 41:1519–1525CrossRefGoogle Scholar
  6. 6.
    Tong Y, Liao J, Zhang Y et al (2010) LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: a HuGE review and meta-analysis. Mol Vis 16:1958–1981Google Scholar
  7. 7.
    Thakkinstian A, Han P, McEvoy M et al (2006) Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration. Hum Mol Genet 15:2784–2790CrossRefGoogle Scholar
  8. 8.
    Yoneyama S, Sakurada Y, Mabuchi F et al (2014) Genetic variants in the SKIV2L gene in exudative age-related macular degeneration in the Japanese population. Ophthalmic Genet 35:151–155CrossRefGoogle Scholar
  9. 9.
    Zerbib J, Richard F, Puche N et al (2010) R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population. Mol Vis 16:1324–1330Google Scholar
  10. 10.
    Rivera A, Fisher SA, Fritsche LG et al (2005) Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet 14:3227–3236CrossRefGoogle Scholar
  11. 11.
    Yu Y, Reynolds R, Fagerness J et al (2011) Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. Invest Ophthalmol Vis Sci 52:4663–4670CrossRefGoogle Scholar
  12. 12.
    Hayashi H, Yamashiro K, Gotoh N et al (2010) CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. Invest Ophthalmol Vis Sci 51:5914–5919CrossRefGoogle Scholar
  13. 13.
    Tian J, Yu W, Qin X et al (2012) Association of genetic polymorphisms and age-related macular degeneration in Chinese population. Invest Ophthalmol Vis Sci 53:4262–4269CrossRefGoogle Scholar
  14. 14.
    Merle BM, Benlian P, Puche N et al (2014) Circulating omega-3 Fatty acids and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 55:2010–2019CrossRefGoogle Scholar
  15. 15.
    Pulido JS, Peterson LM, Mutapcic L et al (2007) LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic. Ophthalmic Genet 28:203–207CrossRefGoogle Scholar
  16. 16.
    Losonczy G, Vajas A, Takács L et al (2012) Effect of the Gas6 c.834 + 7G > A polymorphism and the interaction of known risk factors on AMD pathogenesis in Hungarian patients. PLoS ONE 7:e50181CrossRefGoogle Scholar
  17. 17.
    Tanaka K, Nakayama T, Yuzawa M et al (2011) Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population. Mol Vis 17:2751–2758Google Scholar
  18. 18.
    Kim YH, Kim HS, Mok JW, Joo CK (2013) Gene-gene interactions of CFH and LOC387715/ARMS2 with Korean exudative age-related macular degeneration patients. Ophthalmic Genet 34:151–159CrossRefGoogle Scholar
  19. 19.
    Schick T, Altay L, Viehweger E et al (2016) Genetics of unilateral and bilateral age-related macular degeneration severity stages. PLoS ONE 11:e0156778CrossRefGoogle Scholar
  20. 20.
    Bonyadi M, Foruzandeh Z, Mohammadian T et al (2016) Evaluation of CC-cytokine ligand 2 and complementary factor H Y402H polymorphisms and their interactional association with age-related macular degeneration. Acta Ophthalmol 94:e779–e785CrossRefGoogle Scholar
  21. 21.
    Goto A, Akahori M, Okamoto H et al (2009) Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population. J Ocul Biol Dis Inform 2:164–175CrossRefGoogle Scholar
  22. 22.
    Hautamäki A, Seitsonen S, Holopainen JM et al (2015) The genetic variant rs4073 A → T of the Interleukin-8 promoter region is associated with the earlier onset of exudative age-related macular degeneration. Acta Ophthalmol 93:726–733CrossRefGoogle Scholar
  23. 23.
    Recalde S, Fernandez-Robredo P, Altarriba M et al (2008) Age-related macular degeneration genetics. Ophthalmology 115(916–916):e1Google Scholar
  24. 24.
    Tanimoto S, Tamura H, Ue T et al (2007) A polymorphism of LOC387715 gene is associated with age-related macular degeneration in the Japanese population. Neurosci Lett 414:71–74CrossRefGoogle Scholar
  25. 25.
    Xu Y, Guan N, Xu J et al (2008) Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population. Mol Vis 14:1373–1381Google Scholar
  26. 26.
    Fang K, Gao P, Tian J et al (2015) Joint effect of CFH and ARMS2/HTRA1 polymorphisms on neovascular age-related macular degeneration in Chinese population. J Ophthalmol 2015:821918CrossRefGoogle Scholar
  27. 27.
    Teper SJ, Nowińska A, Wylęgała E (2012) A69S and R38X ARMS2 and Y402H CFH gene polymorphisms as risk factors for neovascular age-related macular degeneration in Poland—a brief report. Med Sci Monit 18:PR1–PR3CrossRefGoogle Scholar
  28. 28.
    Jabbarpoor Bonyadi MH, Yaseri M, Bonyadi M, Soheilian M (2016) Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis. Int Ophthalmol.  https://doi.org/10.1007/s10792-016-0413-2 Google Scholar
  29. 29.
    Jabbarpoor Bonyadi MH, Yaseri M, Nikkhah H, Bonyadi M, Soheilian M (2017) Association of risk genotypes of ARMS2/LOC387715 A69S and CFH Y402H with age-related macular degeneration with and without reticular pseudodrusen: a meta-analysis. Acta Ophthalmol.  https://doi.org/10.1111/aos.13494 Google Scholar
  30. 30.
    Wu M, Guo Y, Ma Y et al (2016) Association of two polymorphisms, rs1061170 and rs1410996, in complement factor H with age-related macular degeneration in an Asian population: a meta-analysis. Ophthalmic Res 55:135–144CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Mohammad Hossein Jabbarpoor Bonyadi
    • 1
    Email author
  • Mehdi Yaseri
    • 2
  • Homayoun Nikkhah
    • 1
  • Mortaza Bonyadi
    • 3
  • Rahman Nazari
    • 1
  • Masoud Soheilian
    • 1
  1. 1.Ocular Tissue Engineering Research Center, Ophthalmic Research CenterShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Biostatistics and EpidemiologyTehran University of Medical SciencesTehranIran
  3. 3.Faculty of Natural Sciences, Center of Excellence for BiodiversityUniversity of TabrizTabrizIran

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