Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis
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We designed this meta-analysis to pool studies which have analyzed both CFH (Y402H or I62V) and ARMS2 A69S in the same samples to compare the effect of CFH and ARMS2 in neovascular AMD.
Relevant studies identified and reviewed separately in order to select those for inclusion. Included studies had genotype data of studied groups for both ARMS2 A69S and CFH. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA. Funnel plot and Egger’s regression test used for evaluation of the possible publication bias.
Overall, we included 6676 neovascular AMD cases and 7668 controls. Pooled overall odds ratios (ORs) (95% CI) for neovascular AMD/control were ARMS2 A69S: OR = 2.35 (2.01–2.75) for GT versus GG; OR = 8.57 (6.91–10.64) for TT versus GG; CFH Y402H: OR = 1.94 (1.73–2.18) for CT versus TT; OR = 4.89 (3.96–6.05) for CC versus TT. ARMS2 A69S genotype OR/CFH Y402H genotype OR (homogeneous genotypes): Asia = 2.14, Europe: 1.87, America: 1.82, Middle East: 3.56, pooled: 1.75. ARMS2 A69S genotype OR/CFH Y402H genotype OR (heterogeneous genotypes): Asia = 0.93, Europe: 1.39, America: 2.06, Middle East: 1.20, pooled: 1.21. ARMS2 A69S risk genotypes have stronger predisposing effect on neovascular AMD compared to CFH Y402H risk genotypes.
Our inclusion criteria to select those studies which have analyzed the effect of these two loci in the same case-control samples showed much stronger effect of ARMS2 A69S in neovascular AMD compared to the CFH Y402H.
KeywordsARMS2/LOC387715 A69S CFH Y402H Wet-type age-related macular degeneration Meta-analysis
Center of Excellence for Biodiversity sponsored this study. The sponsor had no role in the design or conduct of this research.
Compliance with ethical standards
Conflict of interest
There is no conflict of interest. No conflicting relationship exists for any author.
This study adhered to the tenets of the declaration of Helsinki and is approved by the ethics committee of the Shahid Beheshti Medical University.
- 2.Bressler NM (2002) Early detection and treatment of neovascular age-related macular degeneration. J Am Board Fam Pract 15:142–152Google Scholar
- 6.Tong Y, Liao J, Zhang Y et al (2010) LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: a HuGE review and meta-analysis. Mol Vis 16:1958–1981Google Scholar
- 9.Zerbib J, Richard F, Puche N et al (2010) R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population. Mol Vis 16:1324–1330Google Scholar
- 17.Tanaka K, Nakayama T, Yuzawa M et al (2011) Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population. Mol Vis 17:2751–2758Google Scholar
- 23.Recalde S, Fernandez-Robredo P, Altarriba M et al (2008) Age-related macular degeneration genetics. Ophthalmology 115(916–916):e1Google Scholar
- 25.Xu Y, Guan N, Xu J et al (2008) Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population. Mol Vis 14:1373–1381Google Scholar
- 28.Jabbarpoor Bonyadi MH, Yaseri M, Bonyadi M, Soheilian M (2016) Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis. Int Ophthalmol. https://doi.org/10.1007/s10792-016-0413-2 Google Scholar
- 29.Jabbarpoor Bonyadi MH, Yaseri M, Nikkhah H, Bonyadi M, Soheilian M (2017) Association of risk genotypes of ARMS2/LOC387715 A69S and CFH Y402H with age-related macular degeneration with and without reticular pseudodrusen: a meta-analysis. Acta Ophthalmol. https://doi.org/10.1111/aos.13494 Google Scholar