International Ophthalmology

, Volume 39, Issue 2, pp 477–484 | Cite as

Intravitreal aflibercept for the treatment of choroidal neovascularization associated with rubella retinopathy

  • Hasan KiziltoprakEmail author
  • Esat Yetkin
  • Kemal Tekin
  • Mustafa Koc
  • İrfan Akalin
  • Mehmet Yasin Teke
Case Report



To report a case of choroidal neovascularization (CNV) associated with rubella retinopathy (RR) treated with intravitreal aflibercept.

Case presentation

A 15-year-old girl presented a complaint of visual decrease in her left eye. She had a history of hearing decrease since she was 1 year old in addition to patent ductus arteriosus. On ocular examination, the best corrected visual acuity (BCVA) was 20/20 in the right eye and 20/400 in the left eye. Dilated fundus examinations revealed a classic salt-and-pepper appearance in both eyes and a whitish subretinal lesion with retinal hemorrhages in the left macula. Fundus fluorescein angiography (FFA) of the left eye illustrated a pattern of diffuse spotty fluorescence with an active subfoveal CNV lesion, that hyperfluoresces in the early phases of the FFA, maintains well-demarcated borders, and leaks. Spectral domain optical coherence tomography (SD-OCT) revealed thickened and elevated retinal layers at the macula due to the subretinal and intraretinal fluid with foveal and extrafoveal protruding hyper-reflective lesion in the left eye. Single dose of intravitreal aflibercept was performed to the left eye and at the first month after the injection, the BCVA improved to 20/100 and the OCT revealed scar formation. At the follow-up visits, the macula was similar to those at the first month post-injection, and the BCVA was preserved. No additional injections were needed.


Intravitreal aflibercept may be a treatment alternative, which provides satisfactory anatomical and functional results and leads to a better visual acuity in cases with RR complicated by CNV.


Choroidal neovascularization Intravitreal aflibercept Rubella retinopathy 


Compliance with ethical standards

Conflicts of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this paper.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Hasan Kiziltoprak
    • 1
    Email author
  • Esat Yetkin
    • 1
  • Kemal Tekin
    • 2
  • Mustafa Koc
    • 1
  • İrfan Akalin
    • 3
  • Mehmet Yasin Teke
    • 4
  1. 1.Ulucanlar Eye Training and Research HospitalAnkaraTurkey
  2. 2.Kars State HospitalKarsTurkey
  3. 3.Artvin State HospitalArtvinTurkey
  4. 4.Department of Retinal DiseasesUlucanlar Eye Training and Research HospitalAnkaraTurkey

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