International Ophthalmology

, Volume 39, Issue 2, pp 393–396 | Cite as

Dry eye and meibomian gland dysfunction in pseudophakic bullous keratopathy

  • Melis PalamarEmail author
  • Pelin Kiyat
  • Ayse Yagci
Original Paper



To evaluate dry eye tests and meibography of patients with pseudophakic bullous keratopathy (PBK).

Materials and Methods

Thirty-seven patients with PBK were included. The eyes with PBK were compared with the normal pseudophakic fellow eyes. All patients had undergone a detailed ophthalmic examination including corneal and conjunctival fluorescein staining and Oxford scoring, tear film breakup time, Schirmer 1 test, Ocular Surface Disease Index (OSDI) score assessment, lid margin abnormalities, upper and lower eyelid Meibomian gland evaluation using infrared captures of a biomicroscope. Partial or complete loss of the Meibomian glands (Meibomian dropout) was scored for each eyelid from grade 0 (no loss) through grade 3 (lost area was > 2/3 of the total meibomian gland area).


The mean age of the patients was 73.2 ± 8.9 (range, 50–93). Mean tear film breakup time value was statistically lower in PBK eyes (P ≤ 0.001). OSDI, Oxford, lid margin abnormalities, inferior meibography, total meibography score were significantly higher in PBK eyes (P ≤ 0.001). The comparison of Schirmer 1 and superior meibography scores of the groups was insignificant (P = 0.143, P = 0.793, respectively).


The Meibomian gland morphology of the PBK eyes demonstrates significant differences when compared with normal fellow eyes and might be related to evaporative dry eye. For this reason, patients with PBK should be monitored for Meibomian gland dysfunction and when needed start prompt treatment in order to prevent further disturbance of the ocular surface.


Bullous keratopathy Dry eye Evaporative dry eye Meibography Meibomian gland dysfunction Pseudophakic bullous keratopathy 


Compliance with ethical standards

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Ege University Faculty of Medicine, Department of OphthalmologyEge Universitesi Tip Fakultesi Hastanesi, Goz Hastaliklari ADBornova, IzmirTurkey

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