International Ophthalmology

, Volume 39, Issue 2, pp 341–345 | Cite as

Mitomycin C 0.02 and 0.002% efficacy in preventing haze after photorefractive keratectomy

  • L. M. CoelhoEmail author
  • R. O. Sieiro
Original Paper



To compare MMC 0.002% efficacy in preventing haze after PRK in relation to MMC 0.02%.

Patients and methods

We conducted a prospective study with patients with myopia or myopic astigmatism undergoing PRK in the same conditions. After PRK, MMC was applied for 30 s in a concentration of 0.02% on the right eye (group 1) and 0.002% on the left eye (group 2). Age, gender, spherical equivalent and haze intensity (1, 3, 6 and 12 months postoperatively) were assessed. Haze was quantified at biomicroscopy (0–4 +). P < 0.05 was considered statistical significant.


We evaluated 130 patients, 77 women and 53 men, with a mean age of 30.2 ± 9 years. The spherical equivalent was − 3.66 D in the group 1 and − 3.77 D in the group 2. In the 1st month after PRK, incidence of haze was 13.9% eyes in group 1 and 14.6% in group 2. In the 3rd month, incidence of haze was 50.0% eyes in group 1 and 48.5% in group 2 which presented with 3 +/4 + traces of haze. In the 12th month, incidence of haze was 7.7% eyes in group 1 and 5.4% in group 2. There was no correlation between haze and age (p = 0.279/0.333), gender (p = 0.345/0.367) or spherical equivalent (p = 0.100/0.054) in groups 1 and 2, respectively. There was no difference in haze between groups 1 and 2 (p = 0.56).


MMC 0.002% was effective in preventing haze after PRK. As MMC long-term safety has not been proved, we suggest its use in a lower concentration, in order to prevent potential complications.


Refractive surgical procedures Photorefractive keratectomy PRK complications Corneal haze Mitomycin C 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Instituto de Olhos de Belo Horizonte (IOBH)Universidade Federal de Minas Gerais (UFMG)Belo HorizonteBrazil
  2. 2.Faculdade de Ciências Médicas de Minas Gerais (FCMMG)Belo HorizonteBrazil

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