Role of topical interferon alpha-2b in ‘mitomycin-C-resistant’ ocular surface squamous neoplasia: our preliminary findings
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To report the clinical presentation of mitomycin-C (MMC)-resistant ocular surface squamous neoplasia (OSSN) and its treatment outcome with topical interferon alpha-2b (IFNα-2b).
A prospective, non-randomised, pilot study enrolling clinically diagnosed OSSN patients. The inclusion criterion was resistance of OSSN to standard topical MMC (0.02%) chemotherapy. The resistance was defined as ‘no clinical response’ in the terms of reduction in tumour size, extension and vascularity after minimum 6 weeks ‘on-cycles’ of MMC. Any previous surgical intervention or recurrent OSSN lesions were excluded. Topical MMC was stopped in all, and topical IFNα-2b (1million IU/ml) eyedrops were prescribed to each patient. At first presentation, the clinical features and side-effect profile of MMC was noted and therapeutic effect of IFNα-2b was clinically monitored at each follow-up. Topical immunotherapy was continued for 24 weeks and a minimum follow-up of 12 weeks was observed after stopping IFNα-2b.
Six patients with a mean age of 62 years met the inclusion criteria. At presentation, all had unilateral, circumscribed, sessile and unifocal lesions with mean dimensions of 7.67 × 5.17 mm. Four patients had temporal lesions while surface keratin, pigmentation and corneal involvement were noted in three lesions, separately. All lesions had dilated and tortuous feeder vessels. All six tumours resolved completely over a mean tumour resolution time of 16 weeks while the total duration of IFNα-2b treatment was 24 weeks. After stopping immunotherapy, a mean of 14.5 weeks follow-up was observed. None showed any recurrence. The approximate cost of total therapy session was 8400 Indian rupees.
The OSSN lesions showing ‘less or no response’ to topical MMC may be shifted to topical recombinant IFNα-2b before proceeding for a surgical excision.
KeywordsOcular surface squamous neoplasia Interferon alpha-2b Topical mitomycin-C Chemotherapy resistance
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The written informed consent was obtained from all the participants before starting topical interferon therapy.