Comparison of corneal endothelial cell analysis in patients with uveitis and healthy subjects
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The aim of this study is to investigate the effect of uveitis in corneal endothelial cell number and morphology by non-contact specular microscopy.
Our cross-sectional study was performed on 56 eyes of uveitis patients and 53 eyes of healthy subjects. Non-contact specular microscopy was performed to all subjects. The cell density (CD), coefficient of variation, cell minimum area (Min) and cell maximum area (Max), the average of cell size (AVG), percent of hexagonality (HEX%), central corneal thickness (CCT), intraocular pressure (IOP) during uveitis and during remission were measured and compared between two groups.
The mean endothelial cell analysis of the patients was 2540 ± 619 cells/mm2, and the mean endothelial cell analysis of the control group was 2834 ± 413 cells/mm2. The difference was statistically significant between the groups (p = 0.01). There was a statistically significant difference between two groups in terms of Max, Min, AVG, and HEX values. However, there was no difference in terms of CCT between two groups. There was a significant negative correlation between CD and IOP during uveitis attack. There was a significant negative correlation between the anterior chamber cell value and CD.
Our results suggested that uveitis affected endothelial cell density, cell size and shape but not the corneal thickness without being influenced by the duration and number of attacks. Increased IOP during uveitis and anterior chamber cell value had an important role on CD in patients with uveitis.
KeywordsSpecular microscopy Endothelial cell density Coefficient of variation The average of cell size Percent of hexagonality
Compliance with ethical standards
Conflict of interest
All authors certify that they have no conflict of interest. Author Hande GUCLU has no conflict of interest; Author Vuslat GURLU has no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Trakya University Faculty of Medicine Ethics Committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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