Nitrite, neopterin levels and tryptophan degradation in allergic conjunctivitis
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The study aims to evaluate changes in neopterin levels and tryptophan degradation which are induced by Th1-type immune response and nitric oxide metabolism which may be involved in allergic inflammation.
Serum nitrite, kynurenine, tryptophan and neopterin levels were evaluated in 36 patients with seasonal allergic conjunctivitis, along with these values in 41 healthy subjects. All these parameters have been compared with symptom and sign scores.
Tryptophan and kynurenine concentrations were not significantly changed, while serum nitrite concentrations were significantly low, and neopterin levels were significantly increased in patients compared to healthy subjects (p < 0.05). There was a significant relationship between symptom scores and serum nitrite levels in patients.
This preliminary study demonstrates that serum nitric oxide metabolism might have a role in allergic conjunctivitis. Serum neopterin levels but not tryptophan metabolism could serve as a biomarker in patients with seasonal allergic conjunctivitis.
KeywordsAllergic conjunctivitis Kynurenine Neopterin Nitrite Tryptophan breakdown
This study was supported by the Scientific Research Council of Atatürk University (Number 2014/169).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
- 14.Baydar T, Kemer OE, Kilicarslan B, Cardak A, Girgin G (2016) Detection of neopterin in tear samples. Pteridines 27(1–2):13–16Google Scholar
- 20.Kositz C, Schroecksnadel K, Grander G, Schennach H, Kofler H, Fuchs D (2008) High serum tryptophan concentration in pollinosis patients is associated with unresponsiveness to pollen extract therapy. Int Arch Allergy Immunol 147(1):35–40. doi: 10.1159/000128584 CrossRefPubMedPubMedCentralGoogle Scholar
- 22.Raitala A, Karjalainen J, Oja SS, Kosunen TU, Hurme M (2006) Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy. Mol Immunol 43(7):1054–1056. doi: 10.1016/j.molimm.2005.06.022 CrossRefPubMedPubMedCentralGoogle Scholar
- 23.Buyuktiryaki B, Sahiner UM, Girgin G, Birben E, Soyer OU, Cavkaytar O, Cetin C, Arik Yilmaz E, Yavuz ST, Kalayci O, Baydar T, Sackesen C (2015) Low Indoleamine 2,3-dioxygenase (IDO) activity in persistent food allergy in children. Allergy. doi: 10.1111/all.12785 CrossRefPubMedPubMedCentralGoogle Scholar